Nodulogenesis and goitrogenesis.

Goitrogenisis is the consequence of a relative iodine deficiency interacting with a genetic predisposition for maladaptation to iodine deficiency. In the long run, the iodine deficiency induces increased H₂O₂ production that leads to an increased mutagenesis, resulting in somatic mutations with a proliferative advantage and thus the induction of thyroid nodules.