Literature DB >> 21509089

Multiple Bone Metastases in a Patient with Differentiated Thyroid Cancer (DTC): Complete resolution following thyroidectomy and four ablation doses of I-131.

Omayma T Elshafie1, Samir Hussein, Aisha Al-Hamdani, Haddia Bererhi, Nicholas Jy Woodhouse.   

Abstract

Multiple bone metastases from a differentiated thyroid cancer are usually incurable. We report the case of a young Omani woman who presented with 8 discrete skeletal lesions three years after a total thyroidectomy. Following four ablation doses of I-131 she has remained in clinical and biochemical remission for over five years. An extraordinary aspect of this case was the persistent refusal of her husband to use contraception either for himself or his wife. This resulted in her treatment being delayed for more than 6 years during which time the patient delivered and breastfed four additional healthy babies.

Entities:  

Keywords:  Differentiated thyroid cancer; I-131 ablation; Resolution of bone metastases; Thyroidectomy

Year:  2010        PMID: 21509089      PMCID: PMC3074654     

Source DB:  PubMed          Journal:  Sultan Qaboos Univ Med J        ISSN: 2075-051X


  11 in total

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Journal:  Endocrinol Metab Clin North Am       Date:  2007-09       Impact factor: 4.741

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Authors:  Furio Pacini; Martin Schlumberger; Henning Dralle; Rossella Elisei; Johannes W A Smit; Wilmar Wiersinga
Journal:  Eur J Endocrinol       Date:  2006-06       Impact factor: 6.664

Review 5.  Ablation of the thyroid remnant and I-131 dose in differentiated thyroid cancer: a meta-analysis revisited.

Authors:  Suhail A R Doi; Nicholas J Woodhouse; Lukman Thalib; Adedayo Onitilo
Journal:  Clin Med Res       Date:  2007-06

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Journal:  Cancer       Date:  1988-01-01       Impact factor: 6.860

Review 7.  Using recombinant human TSH in the management of well-differentiated thyroid cancer: current strategies and future directions.

Authors:  E L Mazzaferri; R T Kloos
Journal:  Thyroid       Date:  2000-09       Impact factor: 6.568

8.  Survival time and "cure" in papillary and follicular thyroid carcinoma with distant metastases: statistics following University of Michigan therapy.

Authors:  W H Beierwaltes; R H Nishiyama; N W Thompson; J E Copp; A Kubo
Journal:  J Nucl Med       Date:  1982-07       Impact factor: 10.057

Review 9.  Bone metastases from differentiated thyroid carcinoma.

Authors:  M M Muresan; P Olivier; J Leclère; F Sirveaux; L Brunaud; M Klein; R Zarnegar; G Weryha
Journal:  Endocr Relat Cancer       Date:  2008-03       Impact factor: 5.678

10.  Recurrent/metastatic thyroid carcinomas false negative for serum thyroglobulin but positive by posttherapy I-131 whole body scans.

Authors:  Eun-Kyung Park; June-Key Chung; Il Han Lim; Do Joon Park; Dong Soo Lee; Myung Chul Lee; Bo Youn Cho
Journal:  Eur J Nucl Med Mol Imaging       Date:  2008-09-09       Impact factor: 9.236

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