OBJECTIVES: The objective of this study was to evaluate the diagnostic value of heart-type fatty acid-binding protein (H-FABP) in patients with acute chest pain and compare it with standard cardiac markers. METHODS: We undertook a prospective evaluation of 100 consecutive patients admitted with acute chest pain suggestive of acute coronary syndromes (ACS). Serum cardiac troponin I (cTnI), cardiac troponin T (cTnT), creatine kinase-MB (CK-MB) mass, myoglobin, and H-FABP were determined at presentation and 2, 4, 8-10, and 16-24 hours after presentation. The main outcome measure was the best sensitivity value within 6 hours after symptom onset. RESULTS: H-FABP peak concentration occurred at 8 hours after symptoms onset and was the most sensitive early marker with 79.9% and 98% of patients with AMI identified at presentation and 2 hours after presentation respectively. The sensitivity of all other cardiac markers (CK-MB mass, cTnI, cTnT, and myoglobin) at presentation was < 62%. The negative predictive value of H-FABP (94%) was also superior to other markers within the first 2 hours of presentation. Myoglobin was the second most sensitive early marker at presentation. Peak sensitivity of cTnI, CK-MB mass, and cTnT were present at 4, 8-10, and 8-10 hours respectively after presentation. CONCLUSION: Combined measurement of H-FABP and cTnI on two occasions during the first 8 hours after symptom onset was sufficiently sensitive and specific for the early diagnosis of most patients with acute MI and may provide advantages over other cardiac marker combinations.
OBJECTIVES: The objective of this study was to evaluate the diagnostic value of heart-type fatty acid-binding protein (H-FABP) in patients with acute chest pain and compare it with standard cardiac markers. METHODS: We undertook a prospective evaluation of 100 consecutive patients admitted with acute chest pain suggestive of acute coronary syndromes (ACS). Serum cardiac troponin I (cTnI), cardiac troponin T (cTnT), creatine kinase-MB (CK-MB) mass, myoglobin, and H-FABP were determined at presentation and 2, 4, 8-10, and 16-24 hours after presentation. The main outcome measure was the best sensitivity value within 6 hours after symptom onset. RESULTS:H-FABP peak concentration occurred at 8 hours after symptoms onset and was the most sensitive early marker with 79.9% and 98% of patients with AMI identified at presentation and 2 hours after presentation respectively. The sensitivity of all other cardiac markers (CK-MB mass, cTnI, cTnT, and myoglobin) at presentation was < 62%. The negative predictive value of H-FABP (94%) was also superior to other markers within the first 2 hours of presentation. Myoglobin was the second most sensitive early marker at presentation. Peak sensitivity of cTnI, CK-MB mass, and cTnT were present at 4, 8-10, and 8-10 hours respectively after presentation. CONCLUSION: Combined measurement of H-FABP and cTnI on two occasions during the first 8 hours after symptom onset was sufficiently sensitive and specific for the early diagnosis of most patients with acute MI and may provide advantages over other cardiac marker combinations.
Authors: J F Glatz; G J van der Vusse; M L Simoons; J A Kragten; M P van Dieijen-Visser; W T Hermens Journal: Clin Chim Acta Date: 1998-04-06 Impact factor: 3.786
Authors: J Ishii; J H Wang; H Naruse; S Taga; M Kinoshita; H Kurokawa; M Iwase; T Kondo; M Nomura; Y Nagamura; Y Watanabe; H Hishida; T Tanaka; K Kawamura Journal: Clin Chem Date: 1997-08 Impact factor: 8.327
Authors: Suresh Govindan; Diederik Wd Kuster; Brian Lin; Daniel J Kahn; Walter P Jeske; Jeanine M Walenga; Fred Leya; Debra Hoppensteadt; Jawed Fareed; Sakthivel Sadayappan Journal: Am J Cardiovasc Dis Date: 2013-06-10
Authors: Anand K Pyati; Basavaraj B Devaranavadagi; Sanjeev L Sajjannar; Shashikant V Nikam; Mohd Shannawaz; Satish Patil Journal: Indian J Clin Biochem Date: 2016-01-13