BACKGROUND: Epidemiological studies have demonstrated a causal link between tobacco smoking and lung cancer. However, lung adenocarcinoma (AC) is also frequently found in non-smokers compared with other non-small cell lung carcinoma (NSCLC) subtypes. MATERIALS AND METHODS: Mutations of both epithelial growth factor receptor (EGFR) and KRAS, and the methylation status of 10 tumor suppressor or tumor-related genes were examined in 62 ACs, and the relationship with smoking status, and the relationship between the genetic alterations and epigenetic alterations were investigated. RESULTS: The frequency of EGFR mutation was strongly correlated with smoking status, and the frequency of KRAS mutation, and methylation of retinoic acid receptor beta (RAR-β), p16, FHIT and RASSF1A were weakly related with smoking status. Inverse correlation was found between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation. CONCLUSION: Tobacco smoking is correlated with the frequencies of EGFR and KRAS mutations as to pathogenesis of ACs.
BACKGROUND: Epidemiological studies have demonstrated a causal link between tobacco smoking and lung cancer. However, lung adenocarcinoma (AC) is also frequently found in non-smokers compared with other non-small cell lung carcinoma (NSCLC) subtypes. MATERIALS AND METHODS: Mutations of both epithelial growth factor receptor (EGFR) and KRAS, and the methylation status of 10 tumor suppressor or tumor-related genes were examined in 62 ACs, and the relationship with smoking status, and the relationship between the genetic alterations and epigenetic alterations were investigated. RESULTS: The frequency of EGFR mutation was strongly correlated with smoking status, and the frequency of KRAS mutation, and methylation of retinoic acid receptor beta (RAR-β), p16, FHIT and RASSF1A were weakly related with smoking status. Inverse correlation was found between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation. CONCLUSION:Tobacco smoking is correlated with the frequencies of EGFR and KRAS mutations as to pathogenesis of ACs.
Authors: Mohd Feroz Mohd Omar; Kosei Ito; Min En Nga; Ross Soo; Bee Keow Peh; Tuty Muliana Ismail; Bhavin Thakkar; Richie Soong; Yoshiaki Ito; Manuel Salto-Tellez Journal: Pathol Oncol Res Date: 2012-06-24 Impact factor: 3.201
Authors: Kit W Tam; Wei Zhang; Junichi Soh; Victor Stastny; Min Chen; Han Sun; Kelsie Thu; Jonathan J Rios; Chenchen Yang; Crystal N Marconett; Suhaida A Selamat; Ite A Laird-Offringa; Ayumu Taguchi; Samir Hanash; David Shames; Xiaotu Ma; Michael Q Zhang; Wan L Lam; Adi Gazdar Journal: J Thorac Oncol Date: 2013-11 Impact factor: 15.609
Authors: Mathewos Tessema; Michael R Rossi; Maria A Picchi; Christin M Yingling; Yong Lin; Suresh S Ramalingam; Steven A Belinsky Journal: Lung Cancer Date: 2018-07-11 Impact factor: 5.705
Authors: M Talikka; N Sierro; N V Ivanov; N Chaudhary; M J Peck; J Hoeng; C R E Coggins; M C Peitsch Journal: Crit Rev Toxicol Date: 2012-09-18 Impact factor: 5.635