| Literature DB >> 21507717 |
Henry Ogbomo1, Jindrich Cinatl, Christopher H Mody, Peter A Forsyth.
Abstract
Malignant gliomas (MGs) are deadly brain tumors with a median survival after resection, radiotherapy and chemotherapy of only 12 months. The natural immunosuppressive state of MG patients and the locally restricted growth of MGs render this neoplasm an excellent target for immunotherapy. Consequently, several failed attempts were made to treat MGs with immune cells. Recent preclinical experimental studies, however, demonstrate that natural killer (NK) cells can kill MGs and therefore hold promise in immunotherapy of MGs. This review describes the experimental and clinical evidence that support the potential of NK cells in therapy of MGs as well as the limitations to NK therapy. Finally, we propose strategies that could circumvent mitigating factors and enhance NK cell therapy for MG patients.Entities:
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Year: 2011 PMID： 21507717 DOI： 10.1016/j.molmed.2011.03.004
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951