PURPOSE: Telomere length plays an important role in chromosomal stability and tumorigenesis, and its measurement in peripheral white blood cell DNA may be a predictor of the development of lung cancer. EXPERIMENTAL DESIGN: Using a new method - monochrome multiplex quantitative PCR - which reduces measurement variability, we compared telomere length relative to standard DNA in white blood cell DNA in 229 incident male lung cancer cases and 229 matched controls within the prospective Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study of male smokers. RESULTS: Median (10th, 90th percentile) telomere length was 1.13 (0.86, 1.45) in cases and 1.08 (0.85, 1.38) in controls (P=0.038). Telomere length was inversely associated with pack-years of smoking (Spearman's correlation r=-0.16, P=0.02) among controls. Compared to subjects with shorter telomere length (≤median), subjects with greater telomere length (>median) had a 1.6-fold (95% CI, 1.06-2.36) increased risk of lung cancer. There was a significant linear relationship between quartiles of telomere length and risk of lung cancer (odds ratios (95% confidence intervals) by quartile: 1.00, 0.98 (0.55-1.73), 1.62 (0.95-2.77), and 1.50 (0.84-2.68); P(trend)=0.05). In addition, subgroup analysis showed that greater telomere length was associated with an increased risk of lung cancer among longer-term smokers (>38 years) (OR, 1.90; 95% CI, 1.00-3.59) but not among shorter-term smokers (≤38 years) (OR, 1.08; 95% CI, 0.56-2.11) (P(interaction)=0.01). CONCLUSIONS: Our results suggest that greater telomere length may be associated with higher risk of lung cancer among male smokers.
PURPOSE: Telomere length plays an important role in chromosomal stability and tumorigenesis, and its measurement in peripheral white blood cell DNA may be a predictor of the development of lung cancer. EXPERIMENTAL DESIGN: Using a new method - monochrome multiplex quantitative PCR - which reduces measurement variability, we compared telomere length relative to standard DNA in white blood cell DNA in 229 incident male lung cancer cases and 229 matched controls within the prospective Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study of male smokers. RESULTS: Median (10th, 90th percentile) telomere length was 1.13 (0.86, 1.45) in cases and 1.08 (0.85, 1.38) in controls (P=0.038). Telomere length was inversely associated with pack-years of smoking (Spearman's correlation r=-0.16, P=0.02) among controls. Compared to subjects with shorter telomere length (≤median), subjects with greater telomere length (>median) had a 1.6-fold (95% CI, 1.06-2.36) increased risk of lung cancer. There was a significant linear relationship between quartiles of telomere length and risk of lung cancer (odds ratios (95% confidence intervals) by quartile: 1.00, 0.98 (0.55-1.73), 1.62 (0.95-2.77), and 1.50 (0.84-2.68); P(trend)=0.05). In addition, subgroup analysis showed that greater telomere length was associated with an increased risk of lung cancer among longer-term smokers (>38 years) (OR, 1.90; 95% CI, 1.00-3.59) but not among shorter-term smokers (≤38 years) (OR, 1.08; 95% CI, 0.56-2.11) (P(interaction)=0.01). CONCLUSIONS: Our results suggest that greater telomere length may be associated with higher risk of lung cancer among male smokers.
Authors: Jin Sung Jang; Yi Young Choi; Won Kee Lee; Jin Eun Choi; Sung Ick Cha; Yeon Jae Kim; Chang Ho Kim; Sin Kam; Tae Hoon Jung; Jae Yong Park Journal: Cancer Sci Date: 2008-04-29 Impact factor: 6.716
Authors: Ulrika Svenson; Katarina Nordfjäll; Birgitta Stegmayr; Jonas Manjer; Peter Nilsson; Björn Tavelin; Roger Henriksson; Per Lenner; Göran Roos Journal: Cancer Res Date: 2008-05-15 Impact factor: 12.701
Authors: Xifeng Wu; Christopher I Amos; Yong Zhu; Hua Zhao; Barton H Grossman; Jerry W Shay; Sherry Luo; Waun Ki Hong; Margaret R Spitz Journal: J Natl Cancer Inst Date: 2003-08-20 Impact factor: 13.506
Authors: Jian-Min Yuan; Kenneth B Beckman; Renwei Wang; Caroline Bull; Jennifer Adams-Haduch; Joyce Y Huang; Aizhen Jin; Patricia Opresko; Anne B Newman; Yun-Ling Zheng; Michael Fenech; Woon-Puay Koh Journal: Int J Cancer Date: 2018-01-25 Impact factor: 7.396
Authors: Beatriz Sanchez-Espiridion; Meng Chen; Joe Y Chang; Charles Lu; David W Chang; Jack A Roth; Xifeng Wu; Jian Gu Journal: Cancer Res Date: 2014-03-11 Impact factor: 12.701
Authors: Jennifer A Doherty; Laurie Grieshober; John R Houck; Matthew J Barnett; Jean De Dieu Tapsoba; Mark Thornquist; Ching-Yun Wang; Gary E Goodman; Chu Chen Journal: Cancer Epidemiol Biomarkers Prev Date: 2018-05-09 Impact factor: 4.254
Authors: Gabriella M Anic; Vernon K Sondak; Jane L Messina; Neil A Fenske; Jonathan S Zager; Basil S Cherpelis; Ji-Hyun Lee; William J Fulp; Pearlie K Epling-Burnette; Jong Y Park; Dana E Rollison Journal: Cancer Epidemiol Date: 2013-03-21 Impact factor: 2.984
Authors: Shannon M Lynch; Jacqueline M Major; Richard Cawthon; Stephanie J Weinstein; Jarmo Virtamo; Qing Lan; Nathaniel Rothman; Demetrius Albanes; Rachael Z Stolzenberg-Solomon Journal: Int J Cancer Date: 2013-06-14 Impact factor: 7.396