Literature DB >> 21506595

Structure and cytotoxicity of phidianidines A and B: first finding of 1,2,4-oxadiazole system in a marine natural product.

Marianna Carbone1, Yan Li, Carlo Irace, Ernesto Mollo, Francesco Castelluccio, Antonio Di Pascale, Guido Cimino, Rita Santamaria, Yue-Wei Guo, Margherita Gavagnin.   

Abstract

Two indole alkaloids, phidianidines A (1) and B (2), exhibiting an uncommon 1,2,4-oxadiazole ring linked to the indole system, have been isolated from the marine opisthobranch mollusk Phidiana militaris. The structures of the two metabolites have been elucidated by spectroscopic techniques. Phidianidines exhibit high cytotoxicity against tumor and nontumor mammalian cell lines in in vitro assays.

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Year:  2011        PMID： 21506595     DOI： 10.1021/ol200234r

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  23 in total

1.  One-step synthesis of azole- and benzazole-based sulfonamides in aqueous media.

Authors:  Hassan Zali-Boeini; Zhaleh Najafi; Bahareh Abtahi; Hajar Golshadi Ghaleshahi
Journal:  Mol Divers       Date:  2015-01-23       Impact factor: 2.943

Review 2.  Marine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance.

Authors:  Maria Letizia Ciavatta; Florence Lefranc; Marianna Carbone; Ernesto Mollo; Margherita Gavagnin; Tania Betancourt; Ramesh Dasari; Alexander Kornienko; Robert Kiss
Journal:  Med Res Rev       Date:  2016-12-07       Impact factor: 12.944

Review 3.  Bioactive Compounds from Marine Heterobranchs.

Authors:  Conxita Avila; Carlos Angulo-Preckler
Journal:  Mar Drugs       Date:  2020-12-21       Impact factor: 5.118

Review 4.  Bioactive natural products from Chinese marine flora and fauna.

Authors:  Zhen-Fang Zhou; Yue-Wei Guo
Journal:  Acta Pharmacol Sin       Date:  2012-09-03       Impact factor: 6.150

Review 5.  High-value compounds from the molluscs of marine and estuarine ecosystems as prospective functional food ingredients: An overview.

Authors:  Kajal Chakraborty; Minju Joy
Journal:  Food Res Int       Date:  2020-08-31       Impact factor: 6.475

6.  Diaminoglyoxime as a versatile reagent in the synthesis of bis(1,2,4-oxadiazoles), 1,2,4-oxadiazolyl-quinazolines and 1,2,4-oxadiazolyl-benzothiazinones.

Authors:  Rahim Hosseinzadeh Khanmiri; Abolghasem Moghimi; Ahmad Shaabani; Hassan Valizadeh; Seik Weng Ng
Journal:  Mol Divers       Date:  2014-08-13       Impact factor: 2.943

7.  Total synthesis and biological evaluation of phidianidines A and B uncovers unique pharmacological profiles at CNS targets.

Authors:  John T Brogan; Sydney L Stoops; Craig W Lindsley
Journal:  ACS Chem Neurosci       Date:  2012-06-27       Impact factor: 4.418

8.  Synthesis of phidianidines A and B.

Authors:  Hong-Yu Lin; Barry B Snider
Journal:  J Org Chem       Date:  2012-05-01       Impact factor: 4.354

9.  Discovery and synthesis of 1,2,4-oxadiazole derivatives as novel inhibitors of Zika, dengue, Japanese encephalitis, and classical swine fever virus infections.

Authors:  Sangwoo Nam; Hyo Gyeong Na; Eun Hye Oh; Eunhye Jung; Yeon Hee Lee; Eun Ju Jeong; Yu-Da Ou; Bin Zhou; Sunjoo Ahn; Jin Soo Shin; Soo Bong Han; Yun Young Go
Journal:  Arch Pharm Res       Date:  2022-04-20       Impact factor: 4.946

Review 10.  Recent progress in neuroactive marine natural products.

Authors:  Ryuichi Sakai; Geoffrey T Swanson
Journal:  Nat Prod Rep       Date:  2014-01-17       Impact factor: 13.423
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