Literature DB >> 21505704

Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole.

Wen Chen1, Xiao-Dong Yang, Yan Li, Li-Juan Yang, Xue-Quan Wang, Gao-Lan Zhang, Hong-Bin Zhang.   

Abstract

A series of novel hybrid compounds between dihydrobenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-1-position with an electron-donating dihydrobenzofuran, and the imidazolyl-3-position with a naphthylacyl or electron-rich phenacyl group, were vital for modulating cytotoxic activity.

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Year:  2011        PMID： 21505704     DOI： 10.1039/c1ob05116d

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  6 in total

1.  Synthesis and structure-activity relationships of EGCG analogues, a recently identified Hsp90 inhibitor.

Authors:  Anuj Khandelwal; Jessica A Hall; Brian S J Blagg
Journal:  J Org Chem       Date:  2013-08-01       Impact factor: 4.354

2.  Synthesis and antitumor activity of aza-brazilan derivatives containing imidazolium salt pharmacophores.

Authors:  Mingqin Huang; Shengzu Duan; Xueqiong Ma; Bicheng Cai; Dongmei Wu; Yan Li; Liang Li; Hongbin Zhang; Xiaodong Yang
Journal:  Medchemcomm       Date:  2019-05-10       Impact factor: 3.597

Review 3.  Structure-Activity Relationship of Benzofuran Derivatives with Potential Anticancer Activity.

Authors:  Joviana Farhat; Lara Alzyoud; Mohammad Alwahsh; Basem Al-Omari
Journal:  Cancers (Basel)       Date:  2022-04-28       Impact factor: 6.575

4.  Biological Evaluation, Molecular Docking Analyses, and ADME Profiling of Certain New Quinazolinones as Anti-colorectal Agents.

Authors:  Nahed N E El-Sayed; Norah M Almaneai; Abir Ben Bacha; Mohamed K El-Ashrey; Maha I Al-Zaben; Zainab M Almarhoon
Journal:  ACS Omega       Date:  2022-05-23

5.  Synthesis, characterization, in vitro SAR study, and preliminary in vivo toxicity evaluation of naphthylmethyl substituted bis-imidazolium salts.

Authors:  Marie R Southerland; Michael A DeBord; Nicholas A Johnson; Steven R Crabtree; Nicolas E Alexander; Michael L Stromyer; Patrick O Wagers; Matthew J Panzner; Chrys Wesdemiotis; Leah P Shriver; Claire A Tessier; Wiley J Youngs
Journal:  Bioorg Med Chem       Date:  2020-11-28       Impact factor: 3.641

6.  Synthesis, characterization, and biological activity of a triphenylphosphonium-containing imidazolium salt against select bladder cancer cell lines.

Authors:  Michael L Stromyer; Marie R Southerland; Uttam Satyal; Rahmat K Sikder; David J Weader; Jessi A Baughman; Wiley J Youngs; Philip H Abbosh
Journal:  Eur J Med Chem       Date:  2019-10-31       Impact factor: 7.088
  6 in total

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