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Literature DB >> 21505480

Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations.

Ulrike Hoffmann¹, Jeong Hyun Lee, Tao Qin, Katharina Eikermann-Haerter, Cenk Ayata.

Abstract

Spreading depression (SD) is an intense depolarization wave implicated in brain injury. In focal ischemia, recurrent peri-infarct depolarization (PID) waves akin to SD worsen the ischemic injury by exacerbating the blood flow-metabolism mismatch. We recently showed that gabapentin suppresses SD. We, therefore, tested gabapentin on PIDs and stroke outcome. Gabapentin pretreatment (200 mg/kg, intravenously) reduced the infarct volume by 23% after transient focal ischemia in mice. However, the frequency and duration of PIDs were not suppressed when recorded for 2 hours during ischemia, suggesting that gabapentin reduces infarct volume independent of PID suppression.

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Year: 2011 PMID： 21505480 PMCID： PMC3137475 DOI： 10.1038/jcbfm.2011.50

Source DB: PubMed Journal: J Cereb Blood Flow Metab ISSN： 0271-678X Impact factor: 6.200

15 in total

1. Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex.

Authors: Anthony J Strong; Peter J Anderson; Helena R Watts; David J Virley; Andrew Lloyd; Elaine A Irving; Toshiaki Nagafuji; Mitsuyoshi Ninomiya; Hajime Nakamura; Andrew K Dunn; Rudolf Graf
Journal: Brain Date: 2007-04 Impact factor: 13.501

2. Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats.

Authors: Anthony J Williams; Charisma C Bautista; Ren-Wu Chen; Jitendra R Dave; Xi-Chun M Lu; Frank C Tortella; Jed A Hartings
Journal: J Pharmacol Exp Ther Date: 2006-05-25 Impact factor: 4.030

3. Vasoconstrictive neurovascular coupling during focal ischemic depolarizations.

Authors: Hwa Kyoung Shin; Andrew K Dunn; Phillip B Jones; David A Boas; Michael A Moskowitz; Cenk Ayata
Journal: J Cereb Blood Flow Metab Date: 2005-12-07 Impact factor: 6.200

4. The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain.

Authors: J C Hunter; K R Gogas; L R Hedley; L O Jacobson; L Kassotakis; J Thompson; D J Fontana
Journal: Eur J Pharmacol Date: 1997-04-18 Impact factor: 4.432

5. Gabapentin suppresses cortical spreading depression susceptibility.

Authors: Ulrike Hoffmann; Ergin Dileköz; Chiho Kudo; Cenk Ayata
Journal: J Cereb Blood Flow Metab Date: 2010-06-30 Impact factor: 6.200

6. Suppression of cortical spreading depression in migraine prophylaxis.

Authors: Cenk Ayata; Hongwei Jin; Chiho Kudo; Turgay Dalkara; Michael A Moskowitz
Journal: Ann Neurol Date: 2006-04 Impact factor: 10.422

7. Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia.

Authors: Gabor C Petzold; Olaf Windmüller; Stephan Haack; Sebastian Major; Katharina Buchheim; Dirk Megow; Siegrun Gabriel; Thomas-Nicolas Lehmann; Christoph Drenckhahn; Oliver Peters; Hartmut Meierkord; Uwe Heinemann; Ulrich Dirnagl; Jens P Dreier
Journal: Stroke Date: 2005-05-05 Impact factor: 7.914

8. Delayed secondary phase of peri-infarct depolarizations after focal cerebral ischemia: relation to infarct growth and neuroprotection.

Authors: Jed A Hartings; Michael L Rolli; X-C May Lu; Frank C Tortella
Journal: J Neurosci Date: 2003-12-17 Impact factor: 6.167

Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations.

1. Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex.

2. Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats.

3. Vasoconstrictive neurovascular coupling during focal ischemic depolarizations.

4. The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain.

5. Gabapentin suppresses cortical spreading depression susceptibility.

6. Suppression of cortical spreading depression in migraine prophylaxis.

7. Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia.

8. Delayed secondary phase of peri-infarct depolarizations after focal cerebral ischemia: relation to infarct growth and neuroprotection.

9. The impact of anesthetics and hyperoxia on cortical spreading depression.

10. Disposition of gabapentin (neurontin) in mice, rats, dogs, and monkeys.

1. Focal Cerebral Ischemia and Reperfusion Induce Brain Injury Through α2δ-1-Bound NMDA Receptors.

2. Metabolite profiling identifies a branched chain amino acid signature in acute cardioembolic stroke.

3. Method parameters' impact on mortality and variability in mouse stroke experiments: a meta-analysis.

Review 4. Spreading depression as a preclinical model of migraine.