| Literature DB >> 21505471 |
Jonny Nachtigall1, Kathrin Schneider, Christina Bruntner, Alan T Bull, Michael Goodfellow, Heidi Zinecker, Johannes F Imhoff, Graeme Nicholson, Elisabeth Irran, Roderich D Süssmuth, Hans-Peter Fiedler.
Abstract
Benzoxacystol, a new 1,4-benzoxazine-type metabolite, was produced by strain NTK 935, a marine member of the Streptomyces griseus 16S rRNA clade, isolated from deep-sea sediment collected from the Canary Basin. The structure of benzoxacystol was determined by mass spectrometry, NMR experiments and X-ray analysis. The compound showed an inhibitory activity against the enzyme glycogen synthase kinase 3β and a weak antiproliferative activity against mouse fibroblast cells.Entities:
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Year: 2011 PMID： 21505471 DOI： 10.1038/ja.2011.26
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649