PURPOSE OF REVIEW: To summarize the data related to the association between acetaminophen and allergic diseases, and to try to establish a conclusion regarding the extent to which the association is unbiased and what its strength might be. RECENT FINDINGS: Several studies have shown an association between acetaminophen use during pregnancy and allergic diseases in the offspring. Furthermore, this association has also been found between early exposure and recent exposure to the drug and several allergic conditions. However, other studies did not confirm those associations. Taken together, the available data suggest an unbiased but weak association between acetaminophen consumption and asthma/wheezing. Additional studies are needed to definitely confirm the association with rhinitis, eczema and sensitization. SUMMARY: Although the use of acetaminophen is weakly associated with asthma/wheezing, the widespread use of the drug might have important public health implications. Thus, controlled studies to definitely establish not only causality but also the magnitude in which acetaminophen might increase allergic disorders are needed.
PURPOSE OF REVIEW: To summarize the data related to the association between acetaminophen and allergic diseases, and to try to establish a conclusion regarding the extent to which the association is unbiased and what its strength might be. RECENT FINDINGS: Several studies have shown an association between acetaminophen use during pregnancy and allergic diseases in the offspring. Furthermore, this association has also been found between early exposure and recent exposure to the drug and several allergic conditions. However, other studies did not confirm those associations. Taken together, the available data suggest an unbiased but weak association between acetaminophen consumption and asthma/wheezing. Additional studies are needed to definitely confirm the association with rhinitis, eczema and sensitization. SUMMARY: Although the use of acetaminophen is weakly associated with asthma/wheezing, the widespread use of the drug might have important public health implications. Thus, controlled studies to definitely establish not only causality but also the magnitude in which acetaminophen might increase allergic disorders are needed.
Authors: Shu E Soh; Samuel Shang Ming Lee; Sarah Wenli Hoon; Mae Yun Tan; Anne Goh; Bee Wah Lee; Lynette Pei-Chi Shek; Oon Hoe Teoh; Kenneth Kwek; Seang Mei Saw; Keith Godfrey; Yap Seng Chong; Peter Gluckman; Hugo Ps van Bever Journal: Asia Pac Allergy Date: 2012-04-23
Authors: Eunicia Tan; Irene Braithwaite; Christopher McKinlay; Judith Riley; Karen Hoare; Karaponi Okesene-Gafa; Alex Semprini; Nicolette Sheridan; Cameron Grant; David Johnson; Mark Weatherall; Innes Asher; Richard Beasley; Stuart R Dalziel Journal: BMJ Open Date: 2020-12-10 Impact factor: 2.692