| Literature DB >> 21504850 |
Lina Zhu1, Jing Jin, Chang Liu, Chongjing Zhang, Yan Sun, Yanshen Guo, Decai Fu, Xiaoguang Chen, Bailing Xu.
Abstract
A series of novel 2,4-disubstituted quinazoline derivatives were prepared and their inhibitory activities on hPin1 were evaluated. Of all the synthesized compounds, eight compounds displayed inhibitory activities with IC(50) value at the level of 10(-6)mol/L. Preliminary structure-activity relationships were analyzed in details and the binding mode of the titled compounds was predicted using FlexX algorithm. The design and optimization of novel small molecule Pin1 inhibitors will be guided by the results of this report.Entities:
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Year: 2011 PMID： 21504850 DOI： 10.1016/j.bmc.2011.03.058
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641