BACKGROUND: Computed Tomography (CT) is a frequently used staging modality for colon cancer patients in clinical practice. Our aim was to systemically review the available literature on diagnostic accuracy of CT for TNM staging of colon cancer. METHODS: A systematic review of literature was performed. PubMed was searched using MeSH terms with the following search terms: "Tomography, X-Ray Computed" or "Tomography, Spiral Computed" and Colonic Neoplasms. Studies on rectal cancer and studies without separate analyses for the colon were excluded. We identified 779 publications, of which 11 were included for review. Overall and sample-size-weight sensitivity, specificity, accuracy, true-positive, true-negative, false-positive, false-negative, positive and negative predictive values were calculated for T, N and M stages. RESULTS: In the 11 studies, a total of 753 patients with 759 colon cancers underwent CT for staging. Sample-size-weighted sensitivity, specificity and accuracy for T-staging was 77%, 3% and 67%, respectively; for N-staging 76%, 55% and 69%, respectively; and for M-staging 85%, 98% and 95%, respectively. Additional clinical findings were reported in 59/372 (16%) patients, with 12 having a malignant and 47 a benign origin. CONCLUSIONS: While accuracy of CT for TN-staging of colon cancer is only reasonable, the real value of CT is its high accuracy to detect distant metastases.
BACKGROUND: Computed Tomography (CT) is a frequently used staging modality for colon cancerpatients in clinical practice. Our aim was to systemically review the available literature on diagnostic accuracy of CT for TNM staging of colon cancer. METHODS: A systematic review of literature was performed. PubMed was searched using MeSH terms with the following search terms: "Tomography, X-Ray Computed" or "Tomography, Spiral Computed" and Colonic Neoplasms. Studies on rectal cancer and studies without separate analyses for the colon were excluded. We identified 779 publications, of which 11 were included for review. Overall and sample-size-weight sensitivity, specificity, accuracy, true-positive, true-negative, false-positive, false-negative, positive and negative predictive values were calculated for T, N and M stages. RESULTS: In the 11 studies, a total of 753 patients with 759 colon cancers underwent CT for staging. Sample-size-weighted sensitivity, specificity and accuracy for T-staging was 77%, 3% and 67%, respectively; for N-staging 76%, 55% and 69%, respectively; and for M-staging 85%, 98% and 95%, respectively. Additional clinical findings were reported in 59/372 (16%) patients, with 12 having a malignant and 47 a benign origin. CONCLUSIONS: While accuracy of CT for TN-staging of colon cancer is only reasonable, the real value of CT is its high accuracy to detect distant metastases.
Authors: A Carrara; M Motter; D Amabile; L Pellecchia; P Moscatelli; R Pertile; M Barbareschi; N L Decarli; M Ferrari; G Tirone Journal: Int J Colorectal Dis Date: 2020-06-16 Impact factor: 2.571
Authors: Asma A Khan; Vij Mannan; Muhammad Ahad Pervaiz; Aqsa Akram; Elina S Momin; Muhammad Sanusi; Tejasvi Kashyap; Abeer O Elshaikh Journal: Cureus Date: 2022-05-27
Authors: Yanqi Huang; Lan He; Di Dong; Caiyun Yang; Cuishan Liang; Xin Chen; Zelan Ma; Xiaomei Huang; Su Yao; Changhong Liang; Jie Tian; Zaiyi Liu Journal: Chin J Cancer Res Date: 2018-02 Impact factor: 5.087