Literature DB >> 21504105

Photochemical internalization: a new tool for gene and oligonucleotide delivery.

Kristian Berg1, Maria Berstad, Lina Prasmickaite, Anette Weyergang, Pål K Selbo, Ida Hedfors, Anders Høgset.   

Abstract

Photochemical internalization (PCI) is a novel technology for release of endocytosed macromolecules into the cytosol. The technology is based on the use of photosensitizers located in endocytic vesicles. Upon activation by light such photosensitizers induce a release of macromolecules from their compartmentalization in endocytic vesicles. PCI has been shown to increase the biological activity of a large variety of macromolecules and other molecules that do not readily penetrate the plasma membrane, including type I ribosome-inactivating proteins, immunotoxins, plasmids, adenovirus, various oligonucleotides, dendrimer-based delivery of chemotherapeutica and unconjugated chemotherapeutica such as bleomycin and doxorubicin. This review will present the basis for the PCI concept and the most recent significant developments.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 21504105     DOI： 10.1007/128_2010_63

Source DB:  PubMed          Journal:  Top Curr Chem        ISSN： 0340-1022


  10 in total

1.  TAT-mediated photochemical internalization results in cell killing by causing the release of calcium into the cytosol of cells.

Authors:  Nandhini Muthukrishnan; Gregory A Johnson; Jongdoo Lim; Eric E Simanek; Jean-Philippe Pellois
Journal:  Biochim Biophys Acta       Date:  2012-07-03

2.  Photochemical Internalization Enhanced Nonviral Suicide Gene Therapy.

Authors:  Chung-Ho Sun; Kristian Berg; Henry Hirschberg
Journal:  Methods Mol Biol       Date:  2019

3.  Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier.

Authors:  Genesis Zamora; Frederick Wang; Chung-Ho Sun; Anthony Trinidad; Young Jik Kwon; Soo Kyung Cho; Kristian Berg; Steen J Madsen; Henry Hirschberg
Journal:  J Biomed Opt       Date:  2014       Impact factor: 3.170

Review 4.  Photodynamic therapy: one step ahead with self-assembled nanoparticles.

Authors:  Pinar Avci; S Sibel Erdem; Michael R Hamblin
Journal:  J Biomed Nanotechnol       Date:  2014-09       Impact factor: 4.099

5.  Increased sensitivity of glioma cells to 5-fluorocytosine following photo-chemical internalization enhanced nonviral transfection of the cytosine deaminase suicide gene.

Authors:  Frederick Wang; Genesis Zamora; Chung-Ho Sun; Anthony Trinidad; Changho Chun; Young Jik Kwon; Kristian Berg; Steen J Madsen; Henry Hirschberg
Journal:  J Neurooncol       Date:  2014-03-08       Impact factor: 4.130

6.  The photolytic activity of poly-arginine cell penetrating peptides conjugated to carboxy-tetramethylrhodamine is modulated by arginine residue content and fluorophore conjugation site.

Authors:  Nandhini Muthukrishnan; Stephen Donovan; Jean-Philippe Pellois
Journal:  Photochem Photobiol       Date:  2014-06-03       Impact factor: 3.421

Review 7.  Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems.

Authors:  Mahdi Karimi; Amir Ghasemi; Parham Sahandi Zangabad; Reza Rahighi; S Masoud Moosavi Basri; H Mirshekari; M Amiri; Z Shafaei Pishabad; A Aslani; M Bozorgomid; D Ghosh; A Beyzavi; A Vaseghi; A R Aref; L Haghani; S Bahrami; Michael R Hamblin
Journal:  Chem Soc Rev       Date:  2016-03-07       Impact factor: 54.564

8.  Photochemical Internalization of Peptide Antigens Provides a Novel Strategy to Realize Therapeutic Cancer Vaccination.

Authors:  Markus Haug; Gaute Brede; Monika Håkerud; Anne Grete Nedberg; Odrun A Gederaas; Trude H Flo; Victoria T Edwards; Pål K Selbo; Anders Høgset; Øyvind Halaas
Journal:  Front Immunol       Date:  2018-04-04       Impact factor: 7.561

Review 9.  Improving the endosomal escape of cell-penetrating peptides and their cargos: strategies and challenges.

Authors:  Alfredo Erazo-Oliveras; Nandhini Muthukrishnan; Ryan Baker; Ting-Yi Wang; Jean-Philippe Pellois
Journal:  Pharmaceuticals (Basel)       Date:  2012-11-01

10.  Mitochondria-targeted Triphenylamine Derivatives Activatable by Two-Photon Excitation for Triggering and Imaging Cell Apoptosis.

Authors:  Rahima Chennoufi; Houcine Bougherara; Nathalie Gagey-Eilstein; Blaise Dumat; Etienne Henry; Frédéric Subra; Stéphanie Bury-Moné; Florence Mahuteau-Betzer; Patrick Tauc; Marie-Paule Teulade-Fichou; Eric Deprez
Journal:  Sci Rep       Date:  2016-03-07       Impact factor: 4.379
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.