Saxena Vikas1, S Darbhamulla. 1. Indian Veterinary Research Institute, Surgery Division, India. vikasvicky17@rediffmail.com
Abstract
BACKGROUND: The Cinnoline moiety and Sulphonamide moiety both have good antimicrobial properties. METHODS: In the present study both the moieties were condensed to synthesize substituted cinnoline sulphonamide derivatives using intramolecular cyclization followed by diazotization in order to get synergistic activity. RESULTS: These derivatives particularly halogen substituted cinnoline derivatives showed potent antimicrobial activity. CONCLUSION: Further investigations are required to find out possible mechanism of action.
BACKGROUND: The Cinnoline moiety and Sulphonamide moiety both have good antimicrobial properties. METHODS: In the present study both the moieties were condensed to synthesize substituted cinnoline sulphonamide derivatives using intramolecular cyclization followed by diazotization in order to get synergistic activity. RESULTS: These derivatives particularly halogen substituted cinnoline derivatives showed potent antimicrobial activity. CONCLUSION: Further investigations are required to find out possible mechanism of action.
Authors: Barbara Stefańska; Małgorzata Arciemiuk; Maria M Bontemps-Gracz; Maria Dzieduszycka; Agnieszka Kupiec; Sante Martelli; Edward Borowski Journal: Bioorg Med Chem Date: 2003-02-20 Impact factor: 3.641