| Literature DB >> 21502960 |
Roy Bayly1, Jeffrey D Axelrod.
Abstract
Planar cell polarity (PCP) is observed in an array of developmental processes that involve collective cell movement and tissue organization, and its disruption can lead to severe developmental defects. Recent studies in flies and vertebrates have identified new functions for PCP as well as new signalling components, and have proposed new mechanistic models. However, despite this progress, the search to simplify principles of understanding continues and important mechanistic uncertainties still pose formidable challenges.Entities:
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Year: 2011 PMID： 21502960 PMCID： PMC4854751 DOI： 10.1038/nrg2956
Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242