BACKGROUND: While the prevalence of Alzheimer disease (AD) increases with age, little is known about the frequency of dementia with Lewy bodies (DLB) in the oldest old. A retrospective hospital-based study compared the relative prevalence of DLB among very old individuals. METHODS: 1,100 consecutive autopsy cases of demented patients aged over 70 years (mean age: 83.9 ± 5.4 years) were examined using standardized neuropathological methods and current diagnostic consensus criteria. RESULTS: Evaluation of three age groups (8th-10th decade) showed a significant increase in the relative prevalence of AD with cerebrovascular lesions including mixed dementia, while AD with Lewy body (LB) pathology showed a mild but insignificant age-related increase. Both 'pure' AD and vascular dementia showed a mild but insignificant decline, while DLB (without severe AD pathology) decreased progressively. While the severity of Lewy pathology in DLB slightly decreased with age, concomitant Alzheimer-like pathology increased progressively. CONCLUSION: Whether DLB in the oldest old represents a distinct group is a matter of discussion, but the relative prevalence of AD with LB in our sample remained fairly stable.
BACKGROUND: While the prevalence of Alzheimer disease (AD) increases with age, little is known about the frequency of dementia with Lewy bodies (DLB) in the oldest old. A retrospective hospital-based study compared the relative prevalence of DLB among very old individuals. METHODS: 1,100 consecutive autopsy cases of demented patients aged over 70 years (mean age: 83.9 ± 5.4 years) were examined using standardized neuropathological methods and current diagnostic consensus criteria. RESULTS: Evaluation of three age groups (8th-10th decade) showed a significant increase in the relative prevalence of AD with cerebrovascular lesions including mixed dementia, while AD with Lewy body (LB) pathology showed a mild but insignificant age-related increase. Both 'pure' AD and vascular dementia showed a mild but insignificant decline, while DLB (without severe AD pathology) decreased progressively. While the severity of Lewy pathology in DLB slightly decreased with age, concomitant Alzheimer-like pathology increased progressively. CONCLUSION: Whether DLB in the oldest old represents a distinct group is a matter of discussion, but the relative prevalence of AD with LB in our sample remained fairly stable.
Authors: R Scott Mackin; Philip Insel; Jing Zhang; Brian Mohlenhoff; Douglas Galasko; Michael Weiner; Niklas Mattsson Journal: J Alzheimers Dis Date: 2015 Impact factor: 4.472
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Authors: Roderick A Corriveau; Walter J Koroshetz; Jordan T Gladman; Sophia Jeon; Debra Babcock; David A Bennett; S Thomas Carmichael; Susan L-J Dickinson; Dennis W Dickson; Marian Emr; Howard Fillit; Steven M Greenberg; Michael L Hutton; David S Knopman; Jennifer J Manly; Karen S Marder; Claudia S Moy; Creighton H Phelps; Paul A Scott; William W Seeley; Beth-Anne Sieber; Nina B Silverberg; Margaret L Sutherland; Angela Taylor; Christine L Torborg; Salina P Waddy; Amelie K Gubitz; David M Holtzman Journal: Neurology Date: 2017-11-08 Impact factor: 9.910
Authors: H Uetani; T Hirai; M Hashimoto; M Ikeda; M Kitajima; F Sakamoto; D Utsunomiya; S Oda; S Sugiyama; J Matsubara; Y Yamashita Journal: AJNR Am J Neuroradiol Date: 2012-11-01 Impact factor: 3.825
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