Literature DB >> 21502635

Effect of moxifloxacin combined with cefotaxime compared to cefotaxime-gentamicin combination on prevention of white matter damage associated with Escherichia coli sepsis in neonatal rats.

Nolwenn Le Saché1, Olivier Baud, Julien Pansiot, Hoa Pham, Valérie Biran, Nadège Brunel-Meunier, Philippe Bidet, Marie-Dominique Kitzis, Pierre Gressens, Edouard Bingen, Christiane Charriaut-Marlangue, Stéphane Bonacorsi.   

Abstract

Relative to the cefotaxime-gentamicin combination, the moxifloxacin-cefotaxime combination significantly reduced microglial activation and immature oligodendrocyte cell death and delayed myelination in the developing white matter of neonatal rats with experimental Escherichia coli sepsis. These neuroprotective effects were not due to differences in in vivo bactericidal activities or in the systemic inflammatory responses and could be related to the intrinsic immunomodulatory properties of moxifloxacin. Molecular mechanisms underlying the neuroprotective effect of moxifloxacin remain to be elucidated.

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Year:  2011        PMID： 21502635      PMCID： PMC3122449          DOI： 10.1128/AAC.01813-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Very low birth weight preterm infants with early onset neonatal sepsis: the predominance of gram-negative infections continues in the National Institute of Child Health and Human Development Neonatal Research Network, 2002-2003.

Authors:  Barbara J Stoll; Nellie I Hansen; Rosemary D Higgins; Avroy A Fanaroff; Shahnaz Duara; Ronald Goldberg; Abbot Laptook; Michelle Walsh; William Oh; Ellen Hale
Journal:  Pediatr Infect Dis J       Date:  2005-07       Impact factor: 2.129

2.  Pharmacokinetics and elimination of moxifloxacin after oral and intravenous administration in man.

Authors:  H Stass; D Kubitza
Journal:  J Antimicrob Chemother       Date:  1999-05       Impact factor: 5.790

3.  Ciprofloxacin prevents myelination delay in neonatal rats subjected to E. coli sepsis.

Authors:  Gauthier Loron; Paul Olivier; Hélène See; Nolwenn Le Saché; Leslie Angulo; Valérie Biran; Nadège Brunelle; Bernadette Besson-Lescure; Marie-Dominique Kitzis; Julien Pansiot; Edouard Bingen; Pierre Gressens; Stéphane Bonacorsi; Olivier Baud
Journal:  Ann Neurol       Date:  2010-10-27       Impact factor: 10.422

4.  Immunomodulatory and protective effects of moxifloxacin against Candida albicans-induced bronchopneumonia in mice injected with cyclophosphamide.

Authors:  Itamar Shalit; Limor Horev-Azaria; Ina Fabian; Hannah Blau; Naam Kariv; Itsak Shechtman; Hannah Alteraz; Yehudith Kletter
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

Review 5.  Pathogenesis of cerebral white matter injury of prematurity.

Authors:  O Khwaja; J J Volpe
Journal:  Arch Dis Child Fetal Neonatal Ed       Date:  2008-03       Impact factor: 5.747

Review 6.  Immunomodulatory effects of quinolones.

Authors:  Axel Dalhoff; Itamar Shalit
Journal:  Lancet Infect Dis       Date:  2003-06       Impact factor: 25.071

7.  Comparison of cefotaxime, imipenem-cilastatin, ampicillin-gentamicin, and ampicillin-chloramphenicol in the treatment of experimental Escherichia coli bacteremia and meningitis.

Authors:  K S Kim
Journal:  Antimicrob Agents Chemother       Date:  1985-09       Impact factor: 5.191

8.  Rapid eradication of Listeria monocytogenes by moxifloxacin in a murine model of central nervous system listeriosis.

Authors:  Solène Grayo; Marie-Catherine Lott-Desroches; Olivier Dussurget; Renaud Respaud; Arnaud Fontanet; Olivier Join-Lambert; Eric Singlas; Alban Le Monnier
Journal:  Antimicrob Agents Chemother       Date:  2008-06-23       Impact factor: 5.191

9.  Postnatal sepsis, necrotizing entercolitis, and the critical role of systemic inflammation in white matter injury in premature infants.

Authors:  Joseph J Volpe
Journal:  J Pediatr       Date:  2008-08       Impact factor: 4.406

10.  [In vitro activity of moxifloxacin (8-methoxyquinolone) alone or in combination with cefotaxime against group B streptococci].

Authors:  H Jacquier; P Cruaud; I Poilane; E Lachassinne; J Gaudelus; A Collignon
Journal:  Pathol Biol (Paris)       Date:  2007-10-01
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  2 in total

1.  Socioemotional dysfunctions at age 10 years in extremely preterm newborns with late-onset bacteremia.

Authors:  Kikelomo Babata; H Reeve Bright; Elizabeth N Allred; Carmina Erdei; Karl C K Kuban; Robert M Joseph; T Michael O'Shea; Olaf Dammann; Alan Leviton
Journal:  Early Hum Dev       Date:  2018-04-24       Impact factor: 2.079

2.  Narciclasine improves outcome in sepsis among neonatal rats via inhibition of calprotectin and alleviating inflammatory responses.

Authors:  Manoj Kumar Kingsley; Ballambattu Vishnu Bhat; Bhawana Ashok Badhe; Benet Bosco Dhas; Subhash Chandra Parija
Journal:  Sci Rep       Date:  2020-02-19       Impact factor: 4.379
  2 in total

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