BACKGROUND AND OBJECTIVES: To determine the serum levels of procarboxypeptidase A (pro-CPA) and carboxypeptidase A (CPA) in patients with acute and chronic pancreatitis and pancreatic cancer. MATERIALS AND METHODS: Serum samples obtained from 96 patients with acute pancreatitis, 101 patients with chronic pancreatitis, 98 patients with pancreatic cancer and 96 control groups were assayed for biochemical parameters and serum pro-CPA and CPA. RESULTS: Serum pro-CPA and CPA levels were significantly higher in acute and in chronic pancreatic cancer patients compared to control group (p < 0.001). Pancreatic cancer patients had significantly higher serum pro-CPA and CPA levels when compared with acute and chronic pancreatitis cases (p < 0.001). CONCLUSION: These data prove for increased pro-CPA and CPA levels as a biomarker for the diagnosis of pancreatitis and pancreatic cancer.
BACKGROUND AND OBJECTIVES: To determine the serum levels of procarboxypeptidase A (pro-CPA) and carboxypeptidase A (CPA) in patients with acute and chronic pancreatitis and pancreatic cancer. MATERIALS AND METHODS: Serum samples obtained from 96 patients with acute pancreatitis, 101 patients with chronic pancreatitis, 98 patients with pancreatic cancer and 96 control groups were assayed for biochemical parameters and serum pro-CPA and CPA. RESULTS: Serum pro-CPA and CPA levels were significantly higher in acute and in chronic pancreatic cancerpatients compared to control group (p < 0.001). Pancreatic cancerpatients had significantly higher serum pro-CPA and CPA levels when compared with acute and chronic pancreatitis cases (p < 0.001). CONCLUSION: These data prove for increased pro-CPA and CPA levels as a biomarker for the diagnosis of pancreatitis and pancreatic cancer.
Authors: Jeannette Nilsen; Esben Trabjerg; Algirdas Grevys; Claudia Azevedo; Stephen O Brennan; Maria Stensland; John Wilson; Kine Marita Knudsen Sand; Malin Bern; Bjørn Dalhus; Derry C Roopenian; Inger Sandlie; Kasper Dyrberg Rand; Jan Terje Andersen Journal: Commun Biol Date: 2020-04-20
Authors: Ria Uhlig; Hendrina Contreras; Sören Weidemann; Natalia Gorbokon; Anne Menz; Franziska Büscheck; Andreas M Luebke; Martina Kluth; Claudia Hube-Magg; Andrea Hinsch; Doris Höflmayer; Christoph Fraune; Katharina Möller; Christian Bernreuther; Patrick Lebok; Guido Sauter; Waldemar Wilczak; Jakob Izbicki; Daniel Perez; Jörg Schrader; Stefan Steurer; Eike Burandt; Rainer Krech; David Dum; Till Krech; Andreas Marx; Ronald Simon; Sarah Minner; Frank Jacobsen; Till S Clauditz Journal: Am J Surg Pathol Date: 2022-01-01 Impact factor: 6.394