INTRODUCTION: There is a paucity of data regarding efficacy and safety of high dose (>8mg/kg/day) daptomycin. MATERIAL AND METHODS: This ambispective study included all patients that received ≥8 mg/kg/day of daptomycin and had efficacy and safety data. RESULTS: Sixty-nine patients were included. Fifty-nine patients (85.5%) were recorded as having been cured or improved. Six patients (8.6%) had a raised CPK during follow-up with no clinical signs of myopathy in any of them. CONCLUSIONS: High dose daptomycin shows good efficacy without concerns about toxicity.
INTRODUCTION: There is a paucity of data regarding efficacy and safety of high dose (>8mg/kg/day) daptomycin. MATERIAL AND METHODS: This ambispective study included all patients that received ≥8 mg/kg/day of daptomycin and had efficacy and safety data. RESULTS: Sixty-nine patients were included. Fifty-nine patients (85.5%) were recorded as having been cured or improved. Six patients (8.6%) had a raised CPK during follow-up with no clinical signs of myopathy in any of them. CONCLUSIONS: High dose daptomycin shows good efficacy without concerns about toxicity.
Authors: B J Werth; M E Steed; C E Ireland; T T Tran; P Nonejuie; B E Murray; W E Rose; G Sakoulas; J Pogliano; C A Arias; M J Rybak Journal: Antimicrob Agents Chemother Date: 2014-06-23 Impact factor: 5.191
Authors: R Andrew Seaton; Francesco Menichetti; Georgios Dalekos; Andres Beiras-Fernandez; Francisco Nacinovich; Rashidkhan Pathan; Kamal Hamed Journal: Adv Ther Date: 2015-11-26 Impact factor: 3.845
Authors: Artur Timerman; Carlos Brites; Eliana Bicudo; Renato S Grinbaum; Rubens Costa Filho; Claudia D M Carrilho; Andre Bichels; Tânia Barreto Journal: Braz J Infect Dis Date: 2013-07-31 Impact factor: 3.257