| Literature DB >> 2150154 |
J F MacDonald1, M C Bartlett, I Mody, J N Reynolds, M W Salter.
Abstract
Evidence from electropharmacological experimentation favors the hypothesis that the PCP site is intimately associated with the channel domain of the NMDA receptor. But it is too early to state that this site lies deep within the NMDA channel pore. Determining the molecular details of the PCP site will require a complete and detailed kinetic analysis of NMDA single channel behavior. Furthermore, it is likely that hydrophobic receptor site(s) are responsible for some aspects of the blockade by at least some members of the dissociative anaesthetic family.Entities:
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Year: 1990 PMID： 2150154 DOI： 10.1007/978-1-4684-5769-8_4
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622