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Literature DB >> 2150105

Meta-analysis of randomized controlled trials of antibiotic prophylaxis in abdominal hysterectomy.

Abstract

The value of antibiotic prophylaxis in abdominal hysterectomy was reviewed by meta-analysis. Two independent literature searches (1986-1988) yielded 150 relevant papers, however, only 17 (11.3%) papers met our inclusion criteria. The selected papers described prospective, randomized, blinded, placebo-controlled studies of patients undergoing elective abdominal hysterectomy. In 14 of 17 (82%) trials, first- or second-generation cephalosporins were used. Results pooled confirm that antibiotic prophylaxis will reduce infectious morbidity following elective abdominal hysterectomy. Hospital stay is little affected and significant levels of infectious morbidity remain.

Entities: Chemical Species

Mesh：

Substances：
Anti-Bacterial Agents

Year: 1990 PMID： 2150105 DOI： 10.1007/bf01967837

Source DB: PubMed Journal: Pharm Weekbl Sci ISSN： 0167-6555

31 in total

1. Low-dose carbenicillin prophylaxis for vaginal and abdominal hysterectomy.

Authors: J M Roberts; H D Homesley
Journal: Obstet Gynecol Date: 1978-07 Impact factor: 7.661

2. Use of a prophylactic antibiotic in elective major gynecologic operations.

Authors: J L Allen; J F Rampone; C R Wheeless
Journal: Obstet Gynecol Date: 1972-02 Impact factor: 7.661

3. Broad spectrum antibiotics as short term prophylaxis for elective abdominal hysterectomy: comparison of mezlocillin, cefazolin and placebo.

Authors: M Hakim; R Gonen; Z Levitan; M Sharf
Journal: Int J Gynaecol Obstet Date: 1986-04 Impact factor: 3.561

4. Single-dose ceftriaxone versus multi-dose cefotaxime antimicrobial prophylaxis in gynecologic and obstetrical surgery. Preliminary results of a multicenter prospective randomized study.

Authors: P Periti; T Mazzei; S Lamanna; E Mini
Journal: Chemioterapia Date: 1984-10

5. Antimicrobial prophylaxis in hysterectomies: a double-blind, randomized, comparative study of a single dose of piperacillin (2 g) versus a single dose of amoxicillin-clavulanic acid (2.2 g).

Authors: R Janknegt; J P Schepers; J W Haest; G T Fabius; J J Lohman; A P Smeets
Journal: Infection Date: 1993 Jul-Aug Impact factor: 3.553

5 in total

Meta-analysis of randomized controlled trials of antibiotic prophylaxis in abdominal hysterectomy.

1. Low-dose carbenicillin prophylaxis for vaginal and abdominal hysterectomy.

2. Use of a prophylactic antibiotic in elective major gynecologic operations.

3. Broad spectrum antibiotics as short term prophylaxis for elective abdominal hysterectomy: comparison of mezlocillin, cefazolin and placebo.

4. Single-dose ceftriaxone versus multi-dose cefotaxime antimicrobial prophylaxis in gynecologic and obstetrical surgery. Preliminary results of a multicenter prospective randomized study.

5. The effect of a short-term course of antibiotic prophylaxis on patients undergoing total abdominal hysterectomy.

6. Antibiotic prophylaxis for abdominal hysterectomy.

7. Prophylactic antibiotics in gynecologic surgery.

8. The effect of antibiotic prophylaxis on patients undergoing total abdominal hysterectomy. I. Effect on morbidity.

9. Prevention of major infection after elective abdominal hysterectomy: individual determination required.

Review 10. Antibiotic prophylaxis in vaginal hysterectomy: a review.

1. Antibiotic prophylaxis in abdominal hysterectomy, with special reference to the duration of the prophylaxis.

2. Single-dose prophylaxis in hysterectomies. An interim analysis.

3. Antibiotic prophylaxis in gynaecologic procedures.

Review 4. Antibiotic prophylaxis for elective hysterectomy.

5. Antimicrobial prophylaxis in hysterectomies: a double-blind, randomized, comparative study of a single dose of piperacillin (2 g) versus a single dose of amoxicillin-clavulanic acid (2.2 g).