BACKGROUND: In resource-limited settings, CD4 testing is a barrier to antiretroviral therapy initiation in pregnancy. METHODS: We used logistic regression to identify predictors of CD4 cell count ≤ 350 cells/uL in 20,233 pregnant women. RESULTS: The best-performing model included any 3 of: age ≥ 28 years old, hemoglobin ≤ 9.8 g/dL, gestational age ≤ 30 weeks, weight ≤ 64 kg, history of tuberculosis or previous death of an infant prior to one year old. Sensitivity was 45.7% (95% CI: 44.5-47.0), specificity 70.7% (95% CI: 69.6-71.8), and misclassification rate 41.4% (95% CI: 40.5-42.2). CONCLUSION: CD4 triage remains a critical element of maternal HIV care and PMTCT.
BACKGROUND: In resource-limited settings, CD4 testing is a barrier to antiretroviral therapy initiation in pregnancy. METHODS: We used logistic regression to identify predictors of CD4 cell count ≤ 350 cells/uL in 20,233 pregnant women. RESULTS: The best-performing model included any 3 of: age ≥ 28 years old, hemoglobin ≤ 9.8 g/dL, gestational age ≤ 30 weeks, weight ≤ 64 kg, history of tuberculosis or previous death of an infant prior to one year old. Sensitivity was 45.7% (95% CI: 44.5-47.0), specificity 70.7% (95% CI: 69.6-71.8), and misclassification rate 41.4% (95% CI: 40.5-42.2). CONCLUSION:CD4 triage remains a critical element of maternal HIV care and PMTCT.
Authors: Megan E O'Brien; Roland Kupka; Gernard I Msamanga; Elmar Saathoff; David J Hunter; Wafaie W Fawzi Journal: J Acquir Immune Defic Syndr Date: 2005-10-01 Impact factor: 3.731
Authors: Louise Kuhn; Grace M Aldrovandi; Moses Sinkala; Chipepo Kankasa; Katherine Semrau; Mwiya Mwiya; Prisca Kasonde; Nancy Scott; Cheswa Vwalika; Jan Walter; Marc Bulterys; Wei-Yann Tsai; Donald M Thea Journal: N Engl J Med Date: 2008-06-04 Impact factor: 91.245
Authors: Elizabeth R Brown; Phelgona Otieno; Dorothy A Mbori-Ngacha; Carey Farquhar; Elizabeth M Obimbo; Ruth Nduati; Julie Overbaugh; Grace C John-Stewart Journal: J Infect Dis Date: 2009-05-01 Impact factor: 5.226
Authors: Ruby Hn Nguyen; Stephen J Gange; David Serwadda; Godfrey Kigozi; Noah Kiwanuka; Nelson K Sewankambo; Fred Wabwire-Mangen; Thomas C Quinn; Maria Wawer; Ronald H Gray Journal: Int J STD AIDS Date: 2006-02 Impact factor: 1.359
Authors: Isaac M Kigozi; Loren M Dobkin; Jeffrey N Martin; Elvin H Geng; Winnie Muyindike; Nneka I Emenyonu; David R Bangsberg; Judith A Hahn Journal: J Acquir Immune Defic Syndr Date: 2009-10-01 Impact factor: 3.731
Authors: Benjamin H Chi; Mohammed I Limbada; Mark J Giganti; Michelle S Li; Maximillian Bweupe; Patrick Musonda; Peggy Bubala; Mwangelwa Mubiana-Mbewe; Namwinga T Chintu; Carolyn Bolton-Moore; Jeffrey S A Stringer Journal: Pediatr Infect Dis J Date: 2013-02 Impact factor: 2.129
Authors: Heather Bailey; Claire L Townsend; Igor Semenenko; Ruslan Malyuta; Mario Cortina-Borja; Claire Thorne Journal: Bull World Health Organ Date: 2013-04-24 Impact factor: 9.408
Authors: Tendai Munthali; Patrick Musonda; Paul Mee; Sehlulekile Gumede; Ab Schaap; Alwyn Mwinga; Caroline Phiri; Nathan Kapata; Charles Michelo; Jim Todd Journal: Health Res Policy Syst Date: 2017-06-13
Authors: Megan Landes; Monique van Lettow; Adrienne K Chan; Isabell Mayuni; Erik J Schouten; Richard A Bedell Journal: PLoS One Date: 2012-10-17 Impact factor: 3.240