OBJECTIVES: Patients diagnosed with RA have an increased risk of some cancers. However, limited data are available on the important issue of prognosis of RA patients with cancer. METHODS: RA patients were identified from the Swedish Hospital Discharge Register by linkage to the Cancer Registry. Follow-up of patients was started from the date of diagnosis of cancer through year 2006. Hazard ratios (HRs) were calculated in cancer patients with RA compared with subjects without RA. RESULTS: A total of 1,411,163 cancer patients were identified in the database, of whom 6309 had a previous hospitalization for RA. Compared with all cancer patients without RA, patients with RA had a worse prognosis, with an HR of 1.29 and 1.31 for cause-specific and overall survival, respectively. For specific cancer sites, skin and breast cancers and non-Hodgkin's lymphoma showed worst survival. Age stratification did not change the results. CONCLUSION: Cancer patients with a previous hospitalization for RA had a worse prognosis for all and many site-specific cancers compared with patients without RA, independent of age at diagnosis and tumour staging. Improvement of survival for cancer patients with RA may require a multidisciplinary approach to accommodate the comorbidity.
OBJECTIVES:Patients diagnosed with RA have an increased risk of some cancers. However, limited data are available on the important issue of prognosis of RApatients with cancer. METHODS:RApatients were identified from the Swedish Hospital Discharge Register by linkage to the Cancer Registry. Follow-up of patients was started from the date of diagnosis of cancer through year 2006. Hazard ratios (HRs) were calculated in cancerpatients with RA compared with subjects without RA. RESULTS: A total of 1,411,163 cancerpatients were identified in the database, of whom 6309 had a previous hospitalization for RA. Compared with all cancerpatients without RA, patients with RA had a worse prognosis, with an HR of 1.29 and 1.31 for cause-specific and overall survival, respectively. For specific cancer sites, skin and breast cancers and non-Hodgkin's lymphoma showed worst survival. Age stratification did not change the results. CONCLUSION:Cancerpatients with a previous hospitalization for RA had a worse prognosis for all and many site-specific cancers compared with patients without RA, independent of age at diagnosis and tumour staging. Improvement of survival for cancerpatients with RA may require a multidisciplinary approach to accommodate the comorbidity.
Authors: Jonas F Ludvigsson; Benjamin Lebwohl; Alberto Rubio-Tapia; Joseph A Murray; Peter H R Green; Anders Ekbom; Fredrik Granath Journal: Eur J Epidemiol Date: 2013-03-05 Impact factor: 8.082
Authors: Lopamudra Das Roy; Jennifer M Curry; Mahnaz Sahraei; Dahlia M Besmer; Amritha Kidiyoor; Helen E Gruber; Pinku Mukherjee Journal: Breast Cancer Res Date: 2013-04-11 Impact factor: 6.466