UNLABELLED: Perfusable tissue index (PTI) is a marker of myocardial viability and requires acquisition of transmission, (15)O-CO, and (15)O-H(2)O scans. The aim of this study was to generate parametric PTI images from a (15)O-H(2)O PET/CT scan without an additional (15)O-CO scan. METHODS: Data from 20 patients undergoing both (15)O-H(2)O and (15)O-CO scans were used, assessing correlation between PTI based on (15)O-CO (PTI(CO)) and on fitted blood volume fractions (PTI(Vb)). In addition, parametric PTI(Vb) images of 10 patients undergoing (15)O-H(2)O PET/CT scans were generated using basis-function methods and compared with PTI(Vb) obtained using nonlinear regression. Simulations were performed to study the effects of noise on PTI(Vb). RESULTS: Correlation between PTI(CO) and PTI(Vb) was high (r(2) = 0.73). Parametric PTI(Vb) correlated well with PTI(Vb) obtained using nonlinear regression (r(2) = 0.91). Simulations showed low sensitivity to noise (coefficient of variation < 10% at 20% noise). CONCLUSION: Parametric PTI images can be generated from a single (15)O-H(2)O PET/CT scan.
UNLABELLED: Perfusable tissue index (PTI) is a marker of myocardial viability and requires acquisition of transmission, (15)O-CO, and (15)O-H(2)O scans. The aim of this study was to generate parametric PTI images from a (15)O-H(2)O PET/CT scan without an additional (15)O-CO scan. METHODS: Data from 20 patients undergoing both (15)O-H(2)O and (15)O-CO scans were used, assessing correlation between PTI based on (15)O-CO (PTI(CO)) and on fitted blood volume fractions (PTI(Vb)). In addition, parametric PTI(Vb) images of 10 patients undergoing (15)O-H(2)O PET/CT scans were generated using basis-function methods and compared with PTI(Vb) obtained using nonlinear regression. Simulations were performed to study the effects of noise on PTI(Vb). RESULTS: Correlation between PTI(CO) and PTI(Vb) was high (r(2) = 0.73). Parametric PTI(Vb) correlated well with PTI(Vb) obtained using nonlinear regression (r(2) = 0.91). Simulations showed low sensitivity to noise (coefficient of variation < 10% at 20% noise). CONCLUSION: Parametric PTI images can be generated from a single (15)O-H(2)O PET/CT scan.
Authors: Stefan de Haan; Hendrik J Harms; Mark Lubberink; Cornelis P Allaart; Ibrahim Danad; Weena J Y Chen; Michaela Diamant; Albert C van Rossum; Hidehiro Iida; Adriaan A Lammertsma; Paul Knaapen Journal: Eur J Nucl Med Mol Imaging Date: 2012-05-11 Impact factor: 9.236
Authors: Stefan A J Timmer; Paul F A Teunissen; Ibrahim Danad; Lourens F H J Robbers; Pieter G H M Raijmakers; Robin Nijveldt; Albert C van Rossum; Adriaan A Lammertsma; Niels van Royen; Paul Knaapen Journal: J Nucl Cardiol Date: 2016-02-02 Impact factor: 5.952
Authors: Maria Grönman; Miikka Tarkia; Christoffer Stark; Tommi Vähäsilta; Tuomas Kiviniemi; Mark Lubberink; Paavo Halonen; Antti Kuivanen; Virva Saunavaara; Tuula Tolvanen; Jarmo Teuho; Mika Teräs; Timo Savunen; Mikko Pietilä; Seppo Ylä-Herttuala; Anne Roivainen; Juhani Knuuti; Antti Saraste Journal: J Nucl Cardiol Date: 2019-07-17 Impact factor: 5.952