BACKGROUND: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) displays microcirculation and permeability by application of contrast-media and diffusion-weighted imaging (DWI) is a tool for quantification of cellularity in the investigated area. Recently published examples cover breast cancer, CNS tumors, head and neck cancer, gastrointestinal cancer, prostate cancer as well as hematologic malignancies. PURPOSE: To investigated the influence of age, sex, and localization of the investigated region on findings of DCE-MRI and DWI. MATERIAL AND METHODS: DCE-MRI-parameters amplitude A and exchange rate constant kep as well as the DWI-parameter ADC of the bone marrow of the lumbar vertebral column of 30 healthy individuals covering the typical range of age of tumor patients were evaluated. ADC was calculated using b=0 and a maximal b value of either 400 or 750 s/mm(2). RESULTS: Amplitude A of DCE-MRI decreased with age (P = 0.01) and amplitude A, exchange rate constant kep as well as ADC based on b = 400 s/mm(2) and b = 750 s/mm(2,) respectively, decreased significantly from the first to the fifth lumbar vertebra with P = 0.02, P = 0.05, P = 0.003, and P = 0.002, respectively. CONCLUSION: Quantitative parameters of functional imaging techniques in bone marrow are influenced by the age of the examined individual and the anatomical location of the investigated region.
BACKGROUND: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) displays microcirculation and permeability by application of contrast-media and diffusion-weighted imaging (DWI) is a tool for quantification of cellularity in the investigated area. Recently published examples cover breast cancer, CNS tumors, head and neck cancer, gastrointestinal cancer, prostate cancer as well as hematologic malignancies. PURPOSE: To investigated the influence of age, sex, and localization of the investigated region on findings of DCE-MRI and DWI. MATERIAL AND METHODS:DCE-MRI-parameters amplitude A and exchange rate constant kep as well as the DWI-parameter ADC of the bone marrow of the lumbar vertebral column of 30 healthy individuals covering the typical range of age of tumorpatients were evaluated. ADC was calculated using b=0 and a maximal b value of either 400 or 750 s/mm(2). RESULTS: Amplitude A of DCE-MRI decreased with age (P = 0.01) and amplitude A, exchange rate constant kep as well as ADC based on b = 400 s/mm(2) and b = 750 s/mm(2,) respectively, decreased significantly from the first to the fifth lumbar vertebra with P = 0.02, P = 0.05, P = 0.003, and P = 0.002, respectively. CONCLUSION: Quantitative parameters of functional imaging techniques in bone marrow are influenced by the age of the examined individual and the anatomical location of the investigated region.
Authors: J Hillengass; M-A Weber; K Kilk; K Listl; B Wagner-Gund; M Hillengass; T Hielscher; A Farid; K Neben; S Delorme; O Landgren; H Goldschmidt Journal: Leukemia Date: 2013-08-20 Impact factor: 11.528
Authors: Maximilian Merz; Thomas M Moehler; Judith Ritsch; Tobias Bäuerle; Christian M Zechmann; Barbara Wagner; Anna Jauch; Dirk Hose; Christina Kunz; Thomas Hielscher; Hendrik Laue; Hartmut Goldschmidt; Stefan Delorme; Jens Hillengass Journal: Eur Radiol Date: 2015-07-29 Impact factor: 5.315
Authors: Dimitrios C Karampinos; Stefan Ruschke; Michael Dieckmeyer; Maximilian Diefenbach; Daniela Franz; Alexandra S Gersing; Roland Krug; Thomas Baum Journal: J Magn Reson Imaging Date: 2017-06-01 Impact factor: 4.813
Authors: Jakob M Møller; Mikkel Østergaard; Henrik S Thomsen; Inge J Sørensen; Ole R Madsen; Susanne J Pedersen Journal: Acta Radiol Open Date: 2020-03-13