PURPOSE: To assess factors associated with adherence, particularly pill burden, to combination antiretroviral therapy (cART) using multivariate models. METHOD: A cross-sectional survey of US adults with a self-reported diagnosis of HIV/AIDS was conducted between April and May 2007. Respondents on a cART regimen of at least 2 nucleoside reverse transcriptase inhibitors plus at least 1 protease inhibitor or non-nucleoside reverse transcriptase inhibitor (n = 461) were included in the analytic sample. Multiple logistic regression models determined independent predictors of complete adherence (defined as never missing or skipping an antiretroviral dose). RESULTS: Fifty-four percent of respondents reported complete adherence to cART. Adherent respondents reported a lower percentage of hospitalizations (11% vs 28%; P < .0001) and emergency room visits (26% vs 34%; P < .09). Respondents taking the single tablet efavirenz/emtricitabine/tenofovir fixed-dose regimen were significantly more likely to have complete adherence than respondents taking other cART regimens (odds ratio [OR] 2.1, P < .05), and higher imputed daily HIV pill count was associated with lower likelihood of complete adherence (OR 0.93, P < .05). CONCLUSION: This study shows the negative impact of higher pill burden on medication adherence, an important factor associated with treatment outcomes in patients with HIV/AIDS.
PURPOSE: To assess factors associated with adherence, particularly pill burden, to combination antiretroviral therapy (cART) using multivariate models. METHOD: A cross-sectional survey of US adults with a self-reported diagnosis of HIV/AIDS was conducted between April and May 2007. Respondents on a cART regimen of at least 2 nucleoside reverse transcriptase inhibitors plus at least 1 protease inhibitor or non-nucleoside reverse transcriptase inhibitor (n = 461) were included in the analytic sample. Multiple logistic regression models determined independent predictors of complete adherence (defined as never missing or skipping an antiretroviral dose). RESULTS: Fifty-four percent of respondents reported complete adherence to cART. Adherent respondents reported a lower percentage of hospitalizations (11% vs 28%; P < .0001) and emergency room visits (26% vs 34%; P < .09). Respondents taking the single tablet efavirenz/emtricitabine/tenofovir fixed-dose regimen were significantly more likely to have complete adherence than respondents taking other cART regimens (odds ratio [OR] 2.1, P < .05), and higher imputed daily HIV pill count was associated with lower likelihood of complete adherence (OR 0.93, P < .05). CONCLUSION: This study shows the negative impact of higher pill burden on medication adherence, an important factor associated with treatment outcomes in patients with HIV/AIDS.
Authors: Amy S Baranoski; Elizabeth Meuser; Helene Hardy; Elizabeth F Closson; Matthew J Mimiaga; Steven A Safren; Pushwaz Virk; Rowena Luk; Paul R Skolnik; Vikram S Kumar Journal: AIDS Care Date: 2013-06-06
Authors: Jemma L O'Connor; Edward M Gardner; Sharon B Mannheimer; Alan R Lifson; Stefan Esser; Edward E Telzak; Andrew N Phillips Journal: J Infect Dis Date: 2012-11-29 Impact factor: 5.226
Authors: Karen Tashima; Gordon Crofoot; Frank L Tomaka; Thomas N Kakuda; Anne Brochot; Tom Van de Casteele; Magda Opsomer; William Garner; Nicolas Margot; Joseph M Custodio; Marshall W Fordyce; Javier Szwarcberg Journal: AIDS Res Ther Date: 2014-12-01 Impact factor: 2.250