INTRODUCTION: The study was performed to quantify the benefit of preoxygenated hyperventilated hypocapnic apnea-induced radiation (PHAIR) for breath hold (BH) time in patients with breast cancer. METHODS AND MATERIALS: We compared in a single blind study 6 healthy volunteers and 10 breast cancer patients using PHAIR. Both groups were subdivided into two arms, each including 4min eupnea and hyperventilation with 20 breaths/min to 19-20mmHG FeCO2 before apnea without (hBH) and with 100% oxygen (ohBH). Apnea times were measured with an in-house breathholding device and an adapted ventilator, and blood and respiration gas parameters through our laboratory. RESULTS: The experiment was well-tolerated by patients without compromising their security. A significant increase in BH was observed upon hBH and ohBH compared to standard breath hold - up to 700% in ohBH. There is evidence that the patients interrupted their breath hold before the actual physiological end. CONCLUSION: PHAIR is a feasible, safe and recommendable technique that could be used to improve BH for high precision radiotherapy. Further research is necessary to obtain a clinical value for this technique.
INTRODUCTION: The study was performed to quantify the benefit of preoxygenated hyperventilated hypocapnic apnea-induced radiation (PHAIR) for breath hold (BH) time in patients with breast cancer. METHODS AND MATERIALS: We compared in a single blind study 6 healthy volunteers and 10 breast cancerpatients using PHAIR. Both groups were subdivided into two arms, each including 4min eupnea and hyperventilation with 20 breaths/min to 19-20mmHG FeCO2 before apnea without (hBH) and with 100% oxygen (ohBH). Apnea times were measured with an in-house breathholding device and an adapted ventilator, and blood and respiration gas parameters through our laboratory. RESULTS: The experiment was well-tolerated by patients without compromising their security. A significant increase in BH was observed upon hBH and ohBH compared to standard breath hold - up to 700% in ohBH. There is evidence that the patients interrupted their breath hold before the actual physiological end. CONCLUSION: PHAIR is a feasible, safe and recommendable technique that could be used to improve BH for high precision radiotherapy. Further research is necessary to obtain a clinical value for this technique.
Authors: Michael J Parkes; Stuart Green; Andrea M Stevens; Sophia Parveen; Rebecca Stephens; Thomas H Clutton-Brock Journal: Br J Radiol Date: 2016-07 Impact factor: 3.039
Authors: Vincent Vakaet; Hans Van Hulle; Max Schoepen; Els Van Caelenberg; Annick Van Greveling; Jeroen Holvoet; Chris Monten; Luc De Baerdemaeker; Wilfried De Neve; Marc Coppens; Liv Veldeman Journal: Clin Transl Radiat Oncol Date: 2021-02-23
Authors: Michael John Parkes; Stuart Green; Jason Cashmore; Qamar Ghafoor; Thomas Clutton-Brock Journal: Br J Radiol Date: 2021-12-21 Impact factor: 3.039