Literature DB >> 21497800

TLR4-dependent activation of inflammatory cytokine response in macrophages by Francisella elongation factor Tu.

Jyotika Sharma1, Bibhuti B Mishra, Qun Li, Judy M Teale.   

Abstract

The bacterial determinants of pulmonary Francisella induced inflammatory responses and their interaction with host components are not clearly defined. In this study, proteomic and immunoblot analyses showed presence of a cytoplasmic protein elongation factor Tu (EF-Tu) in the membrane fractions of virulent Francisella novicida, LVS and SchuS4, but not in an attenuated F. novicida mutant. EF-Tu was immunodominant in mice vaccinated and protected from virulent F. novicida. Moreover, recombinant EF-Tu induced macrophages to produce inflammatory cytokines in a TLR4 dependent manner. This study shows immune stimulatory properties of a cytoplasmic protein EF-Tu expressed on the membrane of virulent Francisella strains.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21497800      PMCID： PMC3106127          DOI： 10.1016/j.cellimm.2011.03.023

Source DB:  PubMed          Journal:  Cell Immunol        ISSN： 0008-8749            Impact factor:   4.868


  22 in total

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  5 in total

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