| Literature DB >> 21497754 |
Stewart Siyan Cao1, Randal J Kaufman.
Abstract
iRhoms are inactive rhomboid-like pseudoproteases that lack essential catalytic residues. Although iRhoms are highly conserved in metazoan species, little is known about their function. In a recent issue of Cell, Zettl et al. (2011) show that iRhoms regulate growth factor signaling through endoplasmic reticulum-associated protein degradation (ERAD).Entities:
Year: 2011 PMID： 21497754 PMCID： PMC3408039 DOI： 10.1016/j.devcel.2011.04.003
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270