OBJECTIVE: We have previously reported that the histologic mode of invasion of oral squamous cell carcinoma (OSCC) is a significant risk factor for pain. Here we sought to determine whether pain is a risk factor for poor prognosis in patients with OSCC. STUDY DESIGN: We evaluated the relationships between overall survival rates and clinicopathologic variables, including gender, age, T- and N-stages, pathologic findings, and pain in 109 consecutive patients with untreated OSCC. RESULTS: Of these 109 patients, 40 (37%) reported spontaneous pain. Univariate analysis showed that the overall survival rates of patients with spontaneous pain was significantly lower than those of patients without pain (P = .002). Multivariate analysis revealed that spontaneous pain and N-stage were significant independent predictors of overall survival rates. CONCLUSIONS: This is the first report showing that spontaneous pain before treatment may be associated with poor prognosis in patients with OSCC.
OBJECTIVE: We have previously reported that the histologic mode of invasion of oral squamous cell carcinoma (OSCC) is a significant risk factor for pain. Here we sought to determine whether pain is a risk factor for poor prognosis in patients with OSCC. STUDY DESIGN: We evaluated the relationships between overall survival rates and clinicopathologic variables, including gender, age, T- and N-stages, pathologic findings, and pain in 109 consecutive patients with untreated OSCC. RESULTS: Of these 109 patients, 40 (37%) reported spontaneous pain. Univariate analysis showed that the overall survival rates of patients with spontaneous pain was significantly lower than those of patients without pain (P = .002). Multivariate analysis revealed that spontaneous pain and N-stage were significant independent predictors of overall survival rates. CONCLUSIONS: This is the first report showing that spontaneous pain before treatment may be associated with poor prognosis in patients with OSCC.
Authors: Matthew J Heussner; Joseph K Folger; Christina Dias; Noura Massri; Albert Dahdah; Paola D Vermeer; Geoffroy Laumet Journal: Anesth Analg Date: 2021-04-01 Impact factor: 6.627
Authors: K G Oliveira; S V von Zeidler; A Z Lamas; J R V de Podestá; A Sena; E D Souza; J Lenzi; E M Lemos; S A Gouvea; N S Bissoli Journal: Braz J Med Biol Res Date: 2014-05-30 Impact factor: 2.590
Authors: Cláudia Maria Pereira; Dayany Sehnem; Estevão Oliveira da Fonseca; Heráclito Fernando Gurgel Barboza; Antônio Carlos Pires de Carvalho; Alexandre F M DaSilva; Vivaldo Moura-Neto; Marcos F DosSantos Journal: Biomed Res Int Date: 2017-10-30 Impact factor: 3.411