| Literature DB >> 21497637 |
Daisuke Ikeno1, Kazuhiko Kimachi, Kayo Ibaragi, Yasuhiro Kudo, Shuro Goto, Koichi Odoh, Shigeyuki Itamura, Takato Odagiri, Masato Tashiro, Yoichiro Kino.
Abstract
The prime-boost response induced by different combinations of four H5N1 vaccines (NIBRG-14 (clade 1), Indo05/2005(H5N1)/PR8-IBCDC-RG2 (clade 2.1), A/Bar-Headed Goose/Qinhai Lake/1A/05 SJ163222 (clade 2.2), and Anhui01/2005(H5N1)-PR8-IBCDC-RG5 (clade 2.3.4)) was evaluated in mice. Clade 1-primed BALB/c mice showed a booster response to all of the other three H5N1 vaccines. Clade 2.2 vaccine was also a good priming vaccine. However, mice primed with clade 2.1 or clade 2.3.4 vaccine did not respond to booster injection with clade 1 vaccine, suggesting that priming might actually inhibit the booster response with some combinations of vaccines belonging to different clades. Analysis of the mechanism involved showed that lymphocytes from primed mice secreted comparable amounts of cytokines with any combination of priming and booster vaccines. Therefore, impairment of B cell immunity specific to certain booster strains may have been involved.Entities:
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Year: 2011 PMID： 21497637 DOI： 10.1016/j.vaccine.2011.03.084
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641