BACKGROUND: Elevated plantar loading has been implicated in the etiology of plantar ulceration in individuals with diabetes mellitus and peripheral neuropathy. Total contact casts and cast walker boots are common off-loading strategies to facilitate ulcer healing and prevent re-ulceration. The purpose of this study was to compare off-loading capabilities of these strategies with respect to plantar loading during barefoot walking. METHODS:Twenty-three individuals with diabetes, peripheral neuropathy, and plantar ulceration were randomly assigned to total contact cast (n=11) or removable cast walker boot (n=12). Each subject underwent plantar loading assessment walking barefoot and wearing the off-loading device. Analysis of covariance was used to compare loading patterns in the off-loading devices for the whole foot, hindfoot, midfoot, and forefoot while accounting for walking speed and barefoot loading. FINDINGS: For the foot as a whole, there were no differences in off-loading between the two techniques. Subjects wearing cast walker boots had greater reductions in forefoot peak pressure, pressure-time integral, maximum force, and force-time integral with respect to barefoot walking. Healing times were similar between groups, but a greater proportion of ulcers healed in total contact casting compared to cast walker boots. INTERPRETATION: In subjects with diabetes, peripheral neuropathy, and plantar ulceration, cast walker boots provided greater load reduction in the forefoot, the most frequent site of diabetic ulceration, though a greater proportion of subjects wearing total contact casts experienced ulcer healing. Taken together, the less effective ulcer healing in cast walker boots despite superior forefoot off-loading suggests an important role for patient compliance in ulcer healing.
RCT Entities:
BACKGROUND: Elevated plantar loading has been implicated in the etiology of plantar ulceration in individuals with diabetes mellitus and peripheral neuropathy. Total contact casts and cast walker boots are common off-loading strategies to facilitate ulcer healing and prevent re-ulceration. The purpose of this study was to compare off-loading capabilities of these strategies with respect to plantar loading during barefoot walking. METHODS: Twenty-three individuals with diabetes, peripheral neuropathy, and plantar ulceration were randomly assigned to total contact cast (n=11) or removable cast walker boot (n=12). Each subject underwent plantar loading assessment walking barefoot and wearing the off-loading device. Analysis of covariance was used to compare loading patterns in the off-loading devices for the whole foot, hindfoot, midfoot, and forefoot while accounting for walking speed and barefoot loading. FINDINGS: For the foot as a whole, there were no differences in off-loading between the two techniques. Subjects wearing cast walker boots had greater reductions in forefoot peak pressure, pressure-time integral, maximum force, and force-time integral with respect to barefoot walking. Healing times were similar between groups, but a greater proportion of ulcers healed in total contact casting compared to cast walker boots. INTERPRETATION: In subjects with diabetes, peripheral neuropathy, and plantar ulceration, cast walker boots provided greater load reduction in the forefoot, the most frequent site of diabetic ulceration, though a greater proportion of subjects wearing total contact casts experienced ulcer healing. Taken together, the less effective ulcer healing in cast walker boots despite superior forefoot off-loading suggests an important role for patient compliance in ulcer healing.
Authors: Ryan T Crews; Biing-Jiun Shen; Laura Campbell; Peter J Lamont; Andrew J M Boulton; Mark Peyrot; Robert S Kirsner; Loretta Vileikyte Journal: Diabetes Care Date: 2016-06-06 Impact factor: 19.112
Authors: Ryan T Crews; Kristin L Schneider; Sai V Yalla; Neil D Reeves; Loretta Vileikyte Journal: Diabetes Metab Res Rev Date: 2016-06-10 Impact factor: 4.876
Authors: David R Sinacore; Mary K Hastings; Kathryn L Bohnert; Michael J Strube; David J Gutekunst; Jeffrey E Johnson Journal: Bone Date: 2017-09-20 Impact factor: 4.398
Authors: Mary K Hastings; Jeffrey E Johnson; Michael J Strube; Charles F Hildebolt; Kathryn L Bohnert; Fred W Prior; David R Sinacore Journal: J Bone Joint Surg Am Date: 2013-07-03 Impact factor: 5.284
Authors: Sicco A Bus; Jaap J van Netten; Anke Ir Kottink; Erik A Manning; Maximilian Spraul; Arend-Jan Woittiez; Jeff G van Baal Journal: Int Wound J Date: 2017-10-23 Impact factor: 3.315