Literature DB >> 21496637

FEN nucleases: bind, bend, fray, cut.

R Scott Williams1, Thomas A Kunkel.   

Abstract

In this issue, Orans et al. (2011) and Tsutakawa et al. (2011) report exciting insights into the molecular principles governing diverse endo- and exonucleolytic cleavage specificities of members of the RAD2/FEN superfamily of nucleases, which have critical roles in DNA replication and maintenance.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 21496637      PMCID： PMC3515068          DOI： 10.1016/j.cell.2011.03.039

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  10 in total

1.  Passing the baton in base excision repair.

Authors:  S H Wilson; T A Kunkel
Journal:  Nat Struct Biol       Date:  2000-03

Review 2.  Envisioning the molecular choreography of DNA base excision repair.

Authors:  S S Parikh; C D Mol; D J Hosfield; J A Tainer
Journal:  Curr Opin Struct Biol       Date:  1999-02       Impact factor: 6.809

3.  Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily.

Authors:  Susan E Tsutakawa; Scott Classen; Brian R Chapados; Andrew S Arvai; L David Finger; Grant Guenther; Christopher G Tomlinson; Peter Thompson; Altaf H Sarker; Binghui Shen; Priscilla K Cooper; Jane A Grasby; John A Tainer
Journal:  Cell       Date:  2011-04-15       Impact factor: 41.582

4.  Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.

Authors:  Jillian Orans; Elizabeth A McSweeney; Ravi R Iyer; Michael A Hast; Homme W Hellinga; Paul Modrich; Lorena S Beese
Journal:  Cell       Date:  2011-04-15       Impact factor: 41.582

5.  Human exonuclease I is required for 5' and 3' mismatch repair.

Authors:  Jochen Genschel; Laura R Bazemore; Paul Modrich
Journal:  J Biol Chem       Date:  2002-01-24       Impact factor: 5.157

6.  Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.

Authors:  D J Hosfield; C D Mol; B Shen; J A Tainer
Journal:  Cell       Date:  1998-10-02       Impact factor: 41.582

7.  The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability.

Authors:  Y H Jin; R Obert; P M Burgers; T A Kunkel; M A Resnick; D A Gordenin
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-17       Impact factor: 11.205

Review 8.  Nucleases: diversity of structure, function and mechanism.

Authors:  Wei Yang
Journal:  Q Rev Biophys       Date:  2010-09-21       Impact factor: 5.318

9.  Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair.

Authors:  Brian R Chapados; David J Hosfield; Seungil Han; Junzhuan Qiu; Biana Yelent; Binghui Shen; John A Tainer
Journal:  Cell       Date:  2004-01-09       Impact factor: 41.582

Review 10.  Functional regulation of FEN1 nuclease and its link to cancer.

Authors:  Li Zheng; Jia Jia; L David Finger; Zhigang Guo; Cindy Zer; Binghui Shen
Journal:  Nucleic Acids Res       Date:  2010-10-06       Impact factor: 16.971
  10 in total
  7 in total

Review 1.  Recognition and repair of chemically heterogeneous structures at DNA ends.

Authors:  Sara N Andres; Matthew J Schellenberg; Bret D Wallace; Percy Tumbale; R Scott Williams
Journal:  Environ Mol Mutagen       Date:  2014-08-11       Impact factor: 3.216

Review 2.  Repair of oxidatively induced DNA damage by DNA glycosylases: Mechanisms of action, substrate specificities and excision kinetics.

Authors:  Miral Dizdaroglu; Erdem Coskun; Pawel Jaruga
Journal:  Mutat Res Rev Mutat Res       Date:  2017-02-16       Impact factor: 5.657

Review 3.  Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases.

Authors:  Jane A Grasby; L David Finger; Susan E Tsutakawa; John M Atack; John A Tainer
Journal:  Trends Biochem Sci       Date:  2011-11-24       Impact factor: 13.807

4.  The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage.

Authors:  Sucheta Mukherjee; William Douglass Wright; Kirk Tevebaugh Ehmsen; Wolf-Dietrich Heyer
Journal:  Nucleic Acids Res       Date:  2014-04-17       Impact factor: 16.971

5.  Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends.

Authors:  Nikesh Patel; John M Atack; L David Finger; Jack C Exell; Peter Thompson; Susan Tsutakawa; John A Tainer; David M Williams; Jane A Grasby
Journal:  Nucleic Acids Res       Date:  2012-02-08       Impact factor: 16.971

6.  Replication and transcription machinery for ranaviruses: components, correlation, and functional architecture.

Authors:  Fei Ke; Xue-Dong Yu; Zi-Hao Wang; Jian-Fang Gui; Qi-Ya Zhang
Journal:  Cell Biosci       Date:  2022-01-06       Impact factor: 7.133

7.  DNA dynamics during early double-strand break processing revealed by non-intrusive imaging of living cells.

Authors:  Hicham Saad; Franck Gallardo; Mathieu Dalvai; Nicolas Tanguy-le-Gac; David Lane; Kerstin Bystricky
Journal:  PLoS Genet       Date:  2014-03-13       Impact factor: 5.917
  7 in total

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