Literature DB >> 2149518

A model of the mechanisms of long-term potentiation in the hippocampus.

T Kitajima1, K Hara.   

Abstract

Long-Term Potentiation (LTP) in the hippocampus has been considered to be a phenomenon closely related to learning and memory in the brain. In this paper, an integrated model of LTP is constructed based on hypotheses about both the mechanism of LTP induction and that of LTP maintenance, that is, the NMDA-receptor channel, protein phosphorylation and protein turnover. The validity of the model is discussed based on the results of computer simulations.

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Year:  1990        PMID： 2149518     DOI： 10.1007/bf00203628

Source DB:  PubMed          Journal:  Biol Cybern        ISSN： 0340-1200            Impact factor:   2.086


  19 in total

1.  A mechanism for memory storage insensitive to molecular turnover: a bistable autophosphorylating kinase.

Authors:  J E Lisman
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

2.  Regulation of brain type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: a Ca2+-triggered molecular switch.

Authors:  S G Miller; M B Kennedy
Journal:  Cell       Date:  1986-03-28       Impact factor: 41.582

3.  Induction of synaptic potentiation in hippocampus by patterned stimulation involves two events.

Authors:  J Larson; G Lynch
Journal:  Science       Date:  1986-05-23       Impact factor: 47.728

Review 4.  Excitatory amino acid transmitters.

Authors:  J C Watkins; R H Evans
Journal:  Annu Rev Pharmacol Toxicol       Date:  1981       Impact factor: 13.820

5.  Memory and molecular turnover.

Authors:  F Crick
Journal:  Nature       Date:  1984 Nov 8-14       Impact factor: 49.962

6.  Inhibitory modulation of long-term potentiation: evidence for a postsynaptic locus of control.

Authors:  R M Douglas; G V Goddard; M Riives
Journal:  Brain Res       Date:  1982-05-27       Impact factor: 3.252

7.  Potentiation of synaptic transmission in the hippocampus by phorbol esters.

Authors:  R C Malenka; D V Madison; R A Nicoll
Journal:  Nature       Date:  1986 May 8-14       Impact factor: 49.962

8.  Long-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by D(-)aminophosphonovalerate.

Authors:  M L Errington; M A Lynch; T V Bliss
Journal:  Neuroscience       Date:  1987-01       Impact factor: 3.590

9.  Stable hippocampal long-term potentiation elicited by 'theta' pattern stimulation.

Authors:  U Staubli; G Lynch
Journal:  Brain Res       Date:  1987-12-01       Impact factor: 3.252

10.  Correlation between long-term potentiation and release of endogenous amino acids from dentate gyrus of anaesthetized rats.

Authors:  T V Bliss; R M Douglas; M L Errington; M A Lynch
Journal:  J Physiol       Date:  1986-08       Impact factor: 5.182
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  6 in total

1.  A model of the mechanism of cooperativity and associativity of long-term potentiation in the hippocampus: a fundamental mechanism of associative memory and learning.

Authors:  T Kitajima; K Hara
Journal:  Biol Cybern       Date:  1991       Impact factor: 2.086

2.  Assessment of frequency-dependent alterations in the level of extracellular Ca2+ in the synaptic cleft.

Authors:  P M Vassilev; J Mitchel; M Vassilev; M Kanazirska; E M Brown
Journal:  Biophys J       Date:  1997-05       Impact factor: 4.033

3.  A component-based FPGA design framework for neuronal ion channel dynamics simulations.

Authors:  Terrence S T Mak; Guy Rachmuth; Kai-Pui Lam; Chi-Sang Poon
Journal:  IEEE Trans Neural Syst Rehabil Eng       Date:  2006-12       Impact factor: 3.802

4.  A biologically motivated and analytically soluble model of collective oscillations in the cortex. I. Theory of weak locking.

Authors:  W Gerstner; R Ritz; J L van Hemmen
Journal:  Biol Cybern       Date:  1993       Impact factor: 2.086

5.  Postsynaptic signal transduction models for long-term potentiation and depression.

Authors:  Tiina Manninen; Katri Hituri; Jeanette Hellgren Kotaleski; Kim T Blackwell; Marja-Leena Linne
Journal:  Front Comput Neurosci       Date:  2010-12-13       Impact factor: 2.380

6.  Behavioral and synaptic circuit features in a zebrafish model of fragile X syndrome.

Authors:  Ming-Chong Ng; Yi-Ling Yang; Kwok-Tung Lu
Journal:  PLoS One       Date:  2013-03-11       Impact factor: 3.240
  6 in total

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