BACKGROUND: Radiological studies on HIV infection in tuberculous meningitis (TBM) in children are limited to small, retrospective studies using CT features. They report that HIV-infected children are less likely to display meningovascular enhancement, tuberculoma formation and obstructive hydrocephalus. No similar MRI-based studies were found in the literature. PURPOSE: The purpose of this study is to compare the MRI features of TBM in HIV-infected and uninfected children. METHODS: Retrospective descriptive study comparing clinical, laboratory and MRI features of 8 HIV-infected and 19 HIV-uninfected children with TBM. RESULTS: Intense basal meningeal enhancement occurred less frequently (p = 0.31) in HIV-infected children whilst cerebral atrophy was more commonly encountered (p = 0.06) Neither finding was however of statistical significance. All HIV-infected children had visible meningeal nodules on MR imaging compared to 72% in HIV-uninfected children with TBM. No differences were noted regarding number or location of infarcts and presence of hydrocephalus. Hydrocephalus in HIV-infected children was exclusively of communicating nature. CONCLUSIONS: The MRI criteria for diagnosis of TBM apply to HIV-infected children. The presence of nodular meningeal disease in all HIV-infected children has not previously been reported and requires further investigation.
BACKGROUND: Radiological studies on HIV infection in tuberculous meningitis (TBM) in children are limited to small, retrospective studies using CT features. They report that HIV-infectedchildren are less likely to display meningovascular enhancement, tuberculoma formation and obstructive hydrocephalus. No similar MRI-based studies were found in the literature. PURPOSE: The purpose of this study is to compare the MRI features of TBM in HIV-infected and uninfected children. METHODS: Retrospective descriptive study comparing clinical, laboratory and MRI features of 8 HIV-infected and 19 HIV-uninfectedchildren with TBM. RESULTS: Intense basal meningeal enhancement occurred less frequently (p = 0.31) in HIV-infectedchildren whilst cerebral atrophy was more commonly encountered (p = 0.06) Neither finding was however of statistical significance. All HIV-infectedchildren had visible meningeal nodules on MR imaging compared to 72% in HIV-uninfectedchildren with TBM. No differences were noted regarding number or location of infarcts and presence of hydrocephalus. Hydrocephalus in HIV-infectedchildren was exclusively of communicating nature. CONCLUSIONS: The MRI criteria for diagnosis of TBM apply to HIV-infectedchildren. The presence of nodular meningeal disease in all HIV-infectedchildren has not previously been reported and requires further investigation.
Authors: Esther M van der Weert; Nienke M Hartgers; H Simon Schaaf; Brian S Eley; Richard D Pitcher; Nicky A Wieselthaler; Ria Laubscher; Peter R Donald; Johan F Schoeman Journal: Pediatr Infect Dis J Date: 2006-01 Impact factor: 2.129
Authors: D Cecchini; J Ambrosioni; C Brezzo; M Corti; A Rybko; M Perez; S Poggi; M Ambroggi Journal: Int J Tuberc Lung Dis Date: 2009-02 Impact factor: 2.373
Authors: Fiona V Cresswell; Angharad G Davis; Kusum Sharma; Robindra Basu Roy; Ahmad Rizal Ganiem; Enock Kagimu; Regan Solomons; Robert J Wilkinson; Nathan C Bahr; Nguyen Thuy Thuong Thuong Journal: Wellcome Open Res Date: 2021-01-28