Physical Activity in the Prevention and Therapy of Breast Cancer.

SUMMARY: Numerous epidemiological and case-control studies have proven the efficacy of physical activity in the prevention of breast cancer. In physically active subjects, the risk reduction averaged 25-30%. According to published data, 30-60 min of exercise per day at a moderate intensity is regarded as the optimal duration. Furthermore, physical activity plays an important role in the therapy of breast cancer, not only after finishing but already during treatment. Among experts, the evidence of a positive impact on the fatigue syndrome and on the quality of life is found sufficiently convincing. Now, the most recent investigations have shown that regular moderate exercise may bring about a prolongation of life. In the present publication, the most important background facts, potential mechanisms, and recommendations for the prevention and therapy of breast cancer are described.