Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Oxidatively generated damage to DNA by UVA radiation in cells and human skin.

Literature DB >> 21494240

Oxidatively generated damage to DNA by UVA radiation in cells and human skin.

Abstract

Exposure of cells and human skin to UVA radiation oxidatively induces damage to DNA that consists mostly of 8-oxo-7,8-dihydroguanine (8-oxoGua), together with relatively minor amounts of oxidized pyrimidine bases and oligonucleotide strand breaks. Singlet oxygen generated by the type II photosensitization mechanism forms 8-oxoGua, with a small contribution by hydroxyl radicals. The mechanisms of UVA-mediated formation of DNA oxidation products indicate the absence of induction of double-strand breaks.

Entities: Chemical Species

Mesh：

Substances：

Year: 2011 PMID： 21494240 DOI： 10.1038/jid.2011.51

Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551

Keyword Cloud
Cited

23 in total

1. Quantification of Thiopurine/UVA-Induced Singlet Oxygen Production.

Authors: Yazhou Zhang; Ashley N Barnes; Xianchun Zhu; Naomi F Campbell; Ruomei Gao
Journal: J Photochem Photobiol A Chem Date: 2011-10-15 Impact factor: 4.291

Review 2. UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer.

Authors: Gerd P Pfeifer; Ahmad Besaratinia
Journal: Photochem Photobiol Sci Date: 2011-08-01 Impact factor: 3.982

Review 3. Noninvasive Facial Rejuvenation. Part 1: Patient-Directed.

Authors: Sarah Jane Commander; Daniel Chang; Abdulla Fakhro; Marjory G Nigro; Edward I Lee
Journal: Semin Plast Surg Date: 2016-08 Impact factor: 2.314

4. A Prospective Double-blind, Placebo-controlled Clinical Trial Evaluating the Efficacy of a Novel Combination of Hyaluronic Acid Serum and Antioxidant Cream for Rejuvenation of the Aging Neck.

Authors: Monica Boen; Marwan Alhaddad; Douglas C Wu; Mitchel P Goldman
Journal: J Clin Aesthet Dermatol Date: 2020-11-01

5. A Topical Mitochondria-Targeted Redox-Cycling Nitroxide Mitigates Oxidative Stress-Induced Skin Damage.

Authors: Rhonda M Brand; Michael W Epperly; J Mark Stottlemyer; Erin M Skoda; Xiang Gao; Song Li; Saiful Huq; Peter Wipf; Valerian E Kagan; Joel S Greenberger; Louis D Falo
Journal: J Invest Dermatol Date: 2016-10-26 Impact factor: 8.551

6. The epigenetic DNA modification 5-carboxylcytosine promotes high levels of cyclobutane pyrimidine dimer formation upon UVB irradiation.

Authors: Sang-In Kim; Gerd P Pfeifer
Journal: Genome Instab Dis Date: 2021-01-02

Oxidatively generated damage to DNA by UVA radiation in cells and human skin.

1. Quantification of Thiopurine/UVA-Induced Singlet Oxygen Production.

Review 2. UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer.

Review 3. Noninvasive Facial Rejuvenation. Part 1: Patient-Directed.

4. A Prospective Double-blind, Placebo-controlled Clinical Trial Evaluating the Efficacy of a Novel Combination of Hyaluronic Acid Serum and Antioxidant Cream for Rejuvenation of the Aging Neck.

5. A Topical Mitochondria-Targeted Redox-Cycling Nitroxide Mitigates Oxidative Stress-Induced Skin Damage.

6. The epigenetic DNA modification 5-carboxylcytosine promotes high levels of cyclobutane pyrimidine dimer formation upon UVB irradiation.

7. Formation of cyclobutane pyrimidine dimers at dipyrimidines containing 5-hydroxymethylcytosine.

Review 8. DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation.

9. UVA-induced DNA double-strand breaks result from the repair of clustered oxidative DNA damages.

Review 10. Protective mechanisms of green tea polyphenols in skin.