Literature DB >> 21494239

New psoriasis susceptibility genes: momentum for skin-barrier disruption.

Eliecer Coto1, Jorge Santos-Juanes, Pablo Coto-Segura, Victoria Alvarez.   

Abstract

The epidermal differentiation complex gene cluster is on chromosome region 1q21.3, where the PSORS4 locus was mapped. A common deletion of two LCE genes (LCE3C_LCE3B-del) was associated with psoriasis. Individuals homozygous for the deletion have an impaired response of the skin barrier to exogenous agents, facilitating the systemic skin inflammation characteristic of psoriasis.

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Year:  2011        PMID： 21494239     DOI： 10.1038/jid.2011.14

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  7 in total

1.  IL17RA gene variants and anti-TNF response among psoriasis patients.

Authors:  A Batalla; E Coto; J Gómez; N Eirís; D González-Fernández; C Gómez-De Castro; E Daudén; M Llamas-Velasco; R Prieto-Perez; F Abad-Santos; G Carretero; F S García; Y B Godoy; L F Cardo; B Alonso; S Iglesias; P Coto-Segura
Journal:  Pharmacogenomics J       Date:  2016-09-27       Impact factor: 3.550

2.  Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.

Authors:  Philip E Stuart; Rajan P Nair; Lam C Tsoi; Trilokraj Tejasvi; Sayantan Das; Hyun Min Kang; Eva Ellinghaus; Vinod Chandran; Kristina Callis-Duffin; Robert Ike; Yanming Li; Xiaoquan Wen; Charlotta Enerbäck; Johann E Gudjonsson; Sulev Kõks; Külli Kingo; Tõnu Esko; Ulrich Mrowietz; Andre Reis; H Erich Wichmann; Christian Gieger; Per Hoffmann; Markus M Nöthen; Juliane Winkelmann; Manfred Kunz; Elvia G Moreta; Philip J Mease; Christopher T Ritchlin; Anne M Bowcock; Gerald G Krueger; Henry W Lim; Stephan Weidinger; Michael Weichenthal; John J Voorhees; Proton Rahman; Peter K Gregersen; Andre Franke; Dafna D Gladman; Gonçalo R Abecasis; James T Elder
Journal:  Am J Hum Genet       Date:  2015-11-28       Impact factor: 11.025

Review 3.  Advances in the Application of Natural Products and the Novel Drug Delivery Systems for Psoriasis.

Authors:  Jin Xie; Shengjie Huang; Haozhou Huang; Xuan Deng; Pengfei Yue; Junzhi Lin; Ming Yang; Li Han; Ding-Kun Zhang
Journal:  Front Pharmacol       Date:  2021-04-21       Impact factor: 5.810

4.  Psoriasis, Is It a Microdamage of Our "Sixth Sense"? A Neurocentric View.

Authors:  Balázs Sonkodi
Journal:  Int J Mol Sci       Date:  2022-10-08       Impact factor: 6.208

5.  The mRNA Expression Profile of Psoriatic Lesion Distinct from Non-Lesion.

Authors:  Xinhua Li; Jianxiao Xing; Fangdi Wang; Juan Li; Junqin Li; Ruixia Hou; Kaiming Zhang
Journal:  Clin Cosmet Investig Dermatol       Date:  2022-09-27

6.  Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era.

Authors:  William R Swindell; Philip E Stuart; Mrinal K Sarkar; John J Voorhees; James T Elder; Andrew Johnston; Johann E Gudjonsson
Journal:  BMC Med Genomics       Date:  2014-05-22       Impact factor: 3.063

7.  Discovery of increased epidermal DNAH10 expression after regeneration of dermis in a randomized with-in person trial - reflections on psoriatic inflammation.

Authors:  Heli Lagus; Mariliis Klaas; Susanna Juteau; Outi Elomaa; Juha Kere; Jyrki Vuola; Viljar Jaks; Esko Kankuri
Journal:  Sci Rep       Date:  2019-12-13       Impact factor: 4.379
  7 in total

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