OBJECTIVE: Smokers admitted to the intensive care unit may receive nicotine replacement therapy to prevent nicotine withdrawal. However, recent studies have questioned the safety of this practice. The objective of this study was to determine the impact of nicotine replacement therapy on the outcomes of critically ill patients. DESIGN: Prospective observational cohort. SETTING: The medical intensive care unit of a tertiary academic hospital. PATIENTS: Active smokers admitted to the intensive care unit. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: After excluding 2,411 patients who did not meet the study inclusion criteria, 330 were included in the study, of which 174 patients received and 156 did not receive nicotine replacement therapy. There were no significant differences in the unadjusted hospital mortality between the two groups: 14 patients (7.8%; 95% confidence interval, 4-12) died in the nicotine replacement therapy group as compared with ten patients (6.3%; 95% confidence interval, 2.6-10.3) in the nonnicotine replacement therapy group (p = .59). After adjusting for severity of illness and propensity score for administration of nicotine replacement therapy on intensive care unit admission, nicotine replacement therapy was not associated with increased hospital mortality (odds ratio, 1.4; 95% confidence interval, 0.5-3.9; p = .51). LIMITATIONS: Single-center observational study. CONCLUSIONS: Nicotine replacement therapy is not associated with increased hospital mortality in critically ill patients. However, we were not able to demonstrate any clinically significant benefit from its use in the intensive care unit setting.
OBJECTIVE: Smokers admitted to the intensive care unit may receive nicotine replacement therapy to prevent nicotine withdrawal. However, recent studies have questioned the safety of this practice. The objective of this study was to determine the impact of nicotine replacement therapy on the outcomes of critically illpatients. DESIGN: Prospective observational cohort. SETTING: The medical intensive care unit of a tertiary academic hospital. PATIENTS: Active smokers admitted to the intensive care unit. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: After excluding 2,411 patients who did not meet the study inclusion criteria, 330 were included in the study, of which 174 patients received and 156 did not receive nicotine replacement therapy. There were no significant differences in the unadjusted hospital mortality between the two groups: 14 patients (7.8%; 95% confidence interval, 4-12) died in the nicotine replacement therapy group as compared with ten patients (6.3%; 95% confidence interval, 2.6-10.3) in the nonnicotine replacement therapy group (p = .59). After adjusting for severity of illness and propensity score for administration of nicotine replacement therapy on intensive care unit admission, nicotine replacement therapy was not associated with increased hospital mortality (odds ratio, 1.4; 95% confidence interval, 0.5-3.9; p = .51). LIMITATIONS: Single-center observational study. CONCLUSIONS:Nicotine replacement therapy is not associated with increased hospital mortality in critically illpatients. However, we were not able to demonstrate any clinically significant benefit from its use in the intensive care unit setting.
Authors: David B Seder; J Michael Schmidt; Neeraj Badjatia; Luis Fernandez; Fred Rincon; Jan Claassen; Errol Gordon; Emmanuel Carrera; Pedro Kurtz; Kiwon Lee; E Sander Connolly; Stephan A Mayer Journal: Neurocrit Care Date: 2011-02 Impact factor: 3.210
Authors: Ben de Jong; Anne Sophie Schuppers; Arriette Kruisdijk-Gerritsen; Maurits Erwin Leo Arbouw; Hubertus Laurentius Antonius van den Oever; Arthur R H van Zanten Journal: Ann Intensive Care Date: 2018-06-07 Impact factor: 6.925
Authors: Quinn R Pack; Aruna Priya; Tara C Lagu; Penelope S Pekow; Auras Atreya; Nancy A Rigotti; Peter K Lindenauer Journal: J Am Heart Assoc Date: 2018-09-18 Impact factor: 5.501