BACKGROUND AND PURPOSE: Several studies suggest that VLBW is associated with a reduced CC size later in life. We aimed to clarify this in a prospective, controlled study of 19-year-olds, hypothesizing that those with LBWs had smaller subregions of CC than the age-matched controls, even after correcting for brain volume. MATERIALS AND METHODS: One hundred thirteen survivors of LBW (BW <2000 grams) without major handicaps and 100 controls underwent a 3T MR examination of the brain. The cross-sectional area of the CC (total callosal area, and the callosal subregions of the genu, truncus, and posterior third) was measured. Callosal areas were adjusted for head size. RESULTS: The posterior third subregion of the CC was significantly smaller in individuals born with a LBW compared with controls, even after adjusting for size of the forebrain. Individuals who were born with a LBW had a smaller CC (mean area, 553.4 mm(2)) than the controls (mean area, 584.1 mm(2)). Differences in total area, however, did not remain statistically significant after adjusting for FBV. CONCLUSIONS: The uncorrected callosal size in 19-years-olds born with LBW was smaller than that of normal controls. However, after adjusting for FBV, the group difference was restricted to the posterior third. The clinical impact of a smaller posterior part needs further investigation.
BACKGROUND AND PURPOSE: Several studies suggest that VLBW is associated with a reduced CC size later in life. We aimed to clarify this in a prospective, controlled study of 19-year-olds, hypothesizing that those with LBWs had smaller subregions of CC than the age-matched controls, even after correcting for brain volume. MATERIALS AND METHODS: One hundred thirteen survivors of LBW (BW <2000 grams) without major handicaps and 100 controls underwent a 3T MR examination of the brain. The cross-sectional area of the CC (total callosal area, and the callosal subregions of the genu, truncus, and posterior third) was measured. Callosal areas were adjusted for head size. RESULTS: The posterior third subregion of the CC was significantly smaller in individuals born with a LBW compared with controls, even after adjusting for size of the forebrain. Individuals who were born with a LBW had a smaller CC (mean area, 553.4 mm(2)) than the controls (mean area, 584.1 mm(2)). Differences in total area, however, did not remain statistically significant after adjusting for FBV. CONCLUSIONS: The uncorrected callosal size in 19-years-olds born with LBW was smaller than that of normal controls. However, after adjusting for FBV, the group difference was restricted to the posterior third. The clinical impact of a smaller posterior part needs further investigation.
Authors: Paul Fearon; Paul O'Connell; Sophia Frangou; Peter Aquino; Chiara Nosarti; Matthew Allin; Mark Taylor; Ann Stewart; Larry Rifkin; Robin Murray Journal: Pediatrics Date: 2004-08 Impact factor: 7.124
Authors: René Westerhausen; Frank Kreuder; Sarah Dos Santos Sequeira; Christof Walter; Wolfgang Woerner; Ralf Arne Wittling; Elisabeth Schweiger; Werner Wittling Journal: Brain Res Cogn Brain Res Date: 2004-11
Authors: K J Rademaker; J N G P Lam; I C Van Haastert; C S P M Uiterwaal; A F Lieftink; F Groenendaal; D E Grobbee; L S de Vries Journal: Semin Perinatol Date: 2004-08 Impact factor: 3.300
Authors: B S Peterson; B Vohr; L H Staib; C J Cannistraci; A Dolberg; K C Schneider; K H Katz; M Westerveld; S Sparrow; A W Anderson; C C Duncan; R W Makuch; J C Gore; L R Ment Journal: JAMA Date: 2000-10-18 Impact factor: 56.272
Authors: Matthew Allin; Max Henderson; John Suckling; Chiara Nosarti; Teresa Rushe; Paul Fearon; Ann L Stewart; E T Bullmore; Larry Rifkin; Robin Murray Journal: Dev Med Child Neurol Date: 2004-01 Impact factor: 5.449
Authors: Chiara Nosarti; Mazin H S Al-Asady; Sophia Frangou; Ann L Stewart; Larry Rifkin; Robin M Murray Journal: Brain Date: 2002-07 Impact factor: 13.501
Authors: Katja Franke; Bea R H Van den Bergh; Susanne R de Rooij; Nasim Kroegel; Peter W Nathanielsz; Florian Rakers; Tessa J Roseboom; Otto W Witte; Matthias Schwab Journal: Neurosci Biobehav Rev Date: 2020-01-28 Impact factor: 8.989