OBJECTIVE: Mandibular osteoradionecrosis (ORN) is a serious complication of radiotherapy (RT) in head and neck cancer patients. The aim of this study was to analyze the incidence of and risk factors for mandibular ORN in squamous cell carcinoma (SCC) of the oral cavity and oropharynx. STUDY DESIGN: Case series with chart review. SETTING: University tertiary care center for head and neck oncology. SUBJECTS AND METHODS: Seventy-three patients treated for stage I to IV SCC of the oral cavity and oropharynx between 2000 and 2007, with a minimum follow-up of 2 years, were included in the study. Treatment modalities included both RT with curative intent and adjuvant RT following tumor surgery. The log-rank test and Cox model were used for univariate and multivariate analyses. RESULTS: The incidence of mandibular ORN was 40% at 5 years. Using univariate analysis, the following risk factors were identified: oral cavity tumors (P < .01), bone invasion (P < .02), any surgery prior to RT (P < .04), and bone surgery (P < .0001). By multivariate analysis, mandibular surgery proved to be the most important risk factor and the only one reaching statistical significance (P < .0002). CONCLUSION: Mandibular ORN is a frequent long-term complication of RT for oral cavity and oropharynx cancers. Mandibular surgery before irradiation is the only independent risk factor. These aspects must be considered when planning treatment for these tumors.
OBJECTIVE: Mandibular osteoradionecrosis (ORN) is a serious complication of radiotherapy (RT) in head and neck cancerpatients. The aim of this study was to analyze the incidence of and risk factors for mandibular ORN in squamous cell carcinoma (SCC) of the oral cavity and oropharynx. STUDY DESIGN: Case series with chart review. SETTING: University tertiary care center for head and neck oncology. SUBJECTS AND METHODS: Seventy-three patients treated for stage I to IV SCC of the oral cavity and oropharynx between 2000 and 2007, with a minimum follow-up of 2 years, were included in the study. Treatment modalities included both RT with curative intent and adjuvant RT following tumor surgery. The log-rank test and Cox model were used for univariate and multivariate analyses. RESULTS: The incidence of mandibular ORN was 40% at 5 years. Using univariate analysis, the following risk factors were identified: oral cavity tumors (P < .01), bone invasion (P < .02), any surgery prior to RT (P < .04), and bone surgery (P < .0001). By multivariate analysis, mandibular surgery proved to be the most important risk factor and the only one reaching statistical significance (P < .0002). CONCLUSION: Mandibular ORN is a frequent long-term complication of RT for oral cavity and oropharynx cancers. Mandibular surgery before irradiation is the only independent risk factor. These aspects must be considered when planning treatment for these tumors.
Authors: Jonas D Batista; Darceny Zanetta-Barbosa; Sérgio V Cardoso; Paula Dechichi; Flaviana S Rocha; Rogério M Pagnoncelli Journal: Lasers Med Sci Date: 2014-06-10 Impact factor: 3.161
Authors: Larissa Sweeny; William P Lancaster; Nichole R Dean; J Scott Magnuson; William R Carroll; Patrick J Louis; Eben L Rosenthal Journal: J Oral Maxillofac Surg Date: 2011-12-16 Impact factor: 1.895
Authors: Nathaniel S Treister; Michael T Brennan; Thomas P Sollecito; Brian L Schmidt; Lauren L Patton; Rebecca Mitchell; Robert I Haddad; Roy B Tishler; Alexander Lin; Ryann Shadick; James S Hodges; Rajesh V Lalla Journal: Cancer Date: 2021-10-19 Impact factor: 6.860
Authors: Marcus Niewald; Kristina Mang; Oliver Barbie; Jochen Fleckenstein; Henrik Holtmann; Wolfgang J Spitzer; Christian Rübe Journal: Springerplus Date: 2014-05-23