Literature DB >> 2149292

Interactions of spironolactone with (+)-[3H]-isradipine and (-)-[3H]-desmethoxyverapamil binding sites in vascular smooth muscle.

J Mironneau1, I Sayet, L Rakotoarisoa, C Dacquet, C Mironneau.   

Abstract

Spironolactone partially inhibited the specific binding of (+)-[3H]-isradipine and (-)-[3H]-desmethoxyverapamil to vascular smooth muscle membranes. It is suggested that spironolactone interacts at a binding site of the calcium channel complex and allosterically modulates ligand binding at receptor sites in the channel.

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Year:  1990        PMID： 2149292      PMCID： PMC1917651          DOI： 10.1111/j.1476-5381.1990.tb12077.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

1.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

2.  Analysis of the properties of binding of calcium-channel activators and inhibitors to dihydropyridine receptors in chick heart membranes.

Authors:  A C Maan; M M Hosey
Journal:  Circ Res       Date:  1987-09       Impact factor: 17.367

3.  Ligand: a versatile computerized approach for characterization of ligand-binding systems.

Authors:  P J Munson; D Rodbard
Journal:  Anal Biochem       Date:  1980-09-01       Impact factor: 3.365

4.  Specific binding of [3H]nitrendipine to membranes from coronary arteries and heart in relation to pharmacological effects. Paradoxical stimulation by diltiazem.

Authors:  A DePover; M A Matlib; S W Lee; G P Dubé; I L Grupp; G Grupp; A Schwartz
Journal:  Biochem Biophys Res Commun       Date:  1982-09-16       Impact factor: 3.575

5.  Desmethoxyverapamil-sensitive calcium channels in rat portal vein smooth muscle.

Authors:  G Loirand; C Dacquet; P Pacaud; L Rakotoarisoa; I Sayet; C Mironneau; J Mironneau
Journal:  Eur J Pharmacol       Date:  1989-08-22       Impact factor: 4.432

6.  Spironolactone inhibition of contraction and calcium channels in rat portal vein.

Authors:  C Dacquet; G Loirand; C Mironneau; J Mironneau; P Pacaud
Journal:  Br J Pharmacol       Date:  1987-11       Impact factor: 8.739

7.  (+)-[3H]-PN 200-110 binding to cell membranes and intact strips of portal vein smooth muscle: characterization and modulation by membrane potential and divalent cations.

Authors:  C Dacquet; G Loirand; L Rakotoarisoa; C Mironneau; J Mironneau
Journal:  Br J Pharmacol       Date:  1989-05       Impact factor: 8.739

Review 8.  Calcium antagonism and calcium entry blockade.

Authors:  T Godfraind; R Miller; M Wibo
Journal:  Pharmacol Rev       Date:  1986-12       Impact factor: 25.468
  8 in total

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