Literature DB >> 2149281

A phase I study of toremifene.

T Tominaga1, O Abe, M Izuo, Y Nomura.   

Abstract

A Phase I study of the new antiestrogenic drug toremifene was carried out in 27 Japanese women, using oral doses of 10-480 mg per day for one or five days. Serum concentrations reached a dose-dependent maximum 2-6 hours after each oral administration. Side effects were generally mild.

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Year:  1990        PMID: 2149281     DOI: 10.1007/bf01807141

Source DB:  PubMed          Journal:  Breast Cancer Res Treat        ISSN: 0167-6806            Impact factor:   4.872


  6 in total

Review 1.  Clinical pharmacokinetics of endocrine agents used in advanced breast cancer.

Authors:  P E Lønning; E A Lien; S Lundgren; S Kvinnsland
Journal:  Clin Pharmacokinet       Date:  1992-05       Impact factor: 6.447

Review 2.  Clinical pharmacokinetics of toremifene.

Authors:  T L Taras; G T Wurz; G R Linares; M W DeGregorio
Journal:  Clin Pharmacokinet       Date:  2000-11       Impact factor: 6.447

Review 3.  Toremifene. A review of its pharmacological properties and clinical efficacy in the management of advanced breast cancer.

Authors:  L R Wiseman; K L Goa
Journal:  Drugs       Date:  1997-07       Impact factor: 9.546

4.  Phase I clinical and pharmacokinetics study of high-dose toremifene in postmenopausal patients with advanced breast cancer.

Authors:  J Bishop; R Murray; L Webster; P Pitt; K Stokes; A Fennessy; I Olver; G Leber
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

5.  High dose toremifene for estrogen and progesterone receptor negative metastatic breast cancer: a phase II trial of the Cancer and Leukemia Group B (CALGB).

Authors:  J J Perry; D A Berry; R B Weiss; D M Hayes; D B Duggan; I C Henderson
Journal:  Breast Cancer Res Treat       Date:  1995       Impact factor: 4.872

6.  Circumvention of daunorubicin resistance by a new tamoxifen derivative, toremifene, in multidrug-resistant cell line.

Authors:  Y Urasaki; T Ueda; T Nakamura
Journal:  Jpn J Cancer Res       Date:  1994-06
  6 in total

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