Literature DB >> 21492741

Virus-induced differential expression of nuclear receptors and coregulators in dendritic cells: implication to interferon production.

Sinnie Sin Man Ng1, Tsung-Hsien Chang, Prafullakumar Tailor, Keiko Ozato, Tomoshige Kino.   

Abstract

We investigated mRNA expression of 49 nuclear hormone receptors (NRs) and 35 transcriptional coregulators in mouse bone marrow-derived dendritic cells (DCs) upon infection with Newcastle Disease virus (NDV) or murine cytomegalovirus (MCMV). These viruses regulated mRNA expression of some NRs among which NOR1 and LXRα were highly induced at mRNA and protein levels. Exogenous expression of the latter NRs repressed IRF3- or IRF7-induced transactivation of the interferon β promoter and NDV infection further potentiated their repressive effect. The viral infection also significantly regulated mRNA expression of some coregulators, including HDAC1. Toll-like receptor ligands regulated NR and coregulator mRNA expression similar to the viruses. Thus, NRs and coregulators are integral components of DC-organizing anti-viral response wherein NOR1 and LXRα participate in regulating interferon production.
Copyright © 2011. Published by Elsevier B.V.

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Year:  2011        PMID： 21492741      PMCID： PMC3101080          DOI： 10.1016/j.febslet.2011.04.001

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  34 in total

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