| Literature DB >> 21491329 |
T Radivoyevitch1, B Munch-Petersen, L Wang, S Eriksson.
Abstract
The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of ∼0.5 (apparent negative cooperativity) for dT and ∼1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.Entities:
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Year: 2011 PMID： 21491329 PMCID： PMC3097248 DOI： 10.1080/15257770.2011.563765
Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381