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Literature DB >> 2149120

Intraepithelial TcR alpha/beta+ lymphocytes express CD45RO more often than the TcR gamma/delta+ counterparts in coeliac disease.

T S Halstensen¹, I N Farstad, H Scott, O Fausa, P Brandtzaeg.

Abstract

Expression of CD45RO on intraepithelial lymphocytes (IEL) bearing the T-cell receptor (TcR) alpha/beta or gamma/delta was studied in situ by three-colour immunofluorescence on jejunal tissue sections from 21 patients with coeliac disease and eight controls. CD45RA-TcR alpha/beta+ IEL expressed CD45RO significantly more often (75%) than the preferentially expanded TcR gamma/delta+ counterpart (59%). Triple staining for CD3, CD4/8 and CD45RA or CD45RB revealed that all CD3 + 4 - 8 - IEL (taken to be TcR gamma/delta+) expressed CD45RB and none were CD45RA. CD45RO positivity was of the same magnitude (66%) on the predominating monoclonal antibody delta TCS1-reactive fraction of TcR gamma/delta+ cells as on the remainder of the TcR gamma/delta+ subset. These results suggest that gluten exposition in patients with coeliac disease leads to accumulation of CD45RA-, putative antigen-primed memory cells of both TcR phenotypes. The less marked CD45RO expression within the preferentially expanded TcR gamma/delta+ subset of IEL may be of particular biological interest.

Entities: Gene Species

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Year: 1990 PMID： 2149120 PMCID： PMC1384863

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

23 in total

Review 1. TCR gamma delta cells--minor redundant T cell subset or specialized immune system component?

Authors: J A Bluestone; L A Matis
Journal: J Immunol Date: 1989-03-15 Impact factor: 5.422

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Authors: A R Hayward; J Lee; P C Beverley
Journal: Eur J Immunol Date: 1989-04 Impact factor: 5.532

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Authors: M Bonneville; C A Janeway; K Ito; W Haser; I Ishida; N Nakanishi; S Tonegawa
Journal: Nature Date: 1988-12-01 Impact factor: 49.962

4. Cellular events during memory T-cell activation in vitro: the UCHL1 (180,000 MW) determinant is newly synthesized after mitosis.

Authors: A N Akbar; A Timms; G Janossy
Journal: Immunology Date: 1989-02 Impact factor: 7.397

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Authors: M Salmon; G D Kitas; P A Bacon
Journal: J Immunol Date: 1989-08-01 Impact factor: 5.422

6. T lymphocytes in human gut epithelium preferentially express the alpha/beta antigen receptor and are often CD45/UCHL1-positive.

Authors: P Brandtzaeg; V Bosnes; T S Halstensen; H Scott; L M Sollid; K N Valnes
Journal: Scand J Immunol Date: 1989-07 Impact factor: 3.487

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Authors: J Spencer; P G Isaacson; T C Diss; T T MacDonald
Journal: Eur J Immunol Date: 1989-07 Impact factor: 5.532

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Authors: M Streuli; C Morimoto; M Schrieber; S F Schlossman; H Saito
Journal: J Immunol Date: 1988-12-01 Impact factor: 5.422

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Journal: J Exp Med Date: 1989-04-01 Impact factor: 14.307

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Authors: F Powrie; D Mason
Journal: J Exp Med Date: 1989-03-01 Impact factor: 14.307

12 in total

Review 1. Mucosal T cell subsets in coeliac disease: expression of T cell receptor and CD45 isoforms.

Authors: T S Halstensen; P Brandtzaeg
Journal: Immunol Res Date: 1991 Impact factor: 2.829

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Authors: Silvia Lonardi; Vincenzo Villanacci; Luisa Lorenzi; Alberto Lanzini; Francesco Lanzarotto; Nice Carabellese; Umberto Volta; Fabio Facchetti
Journal: Virchows Arch Date: 2013-07-17 Impact factor: 4.064

3. Primary antigen-specific T-cell proliferative responses following presentation of soluble protein antigen by cells from the murine small intestine.

Authors: N A Williams; A D Wilson; M Bailey; P W Bland; C R Stokes
Journal: Immunology Date: 1992-04 Impact factor: 7.397

4. Feeding NOD mice with pig splenocytes induces transferable mechanisms that modulate cellular and humoral xenogeneic reactions against pig spleen or islet cells.

Authors: S You; E Gouin; P Saï
Journal: Clin Exp Immunol Date: 2002-03 Impact factor: 4.330

5. Circulating T lymphocyte subsets in coeliac disease (CoD) patients and healthy family members.

Authors: T O Kerttula; K Holm; J Partanen; A Polvi; M Mäki
Journal: Clin Exp Immunol Date: 1998-03 Impact factor: 4.330

6. The role of small intestinal antigen-presenting cells in the induction of T-cell reactivity to soluble protein antigens: association between aberrant presentation in the lamina propria and oral tolerance.

Authors: H M Harper; L Cochrane; N A Williams
Journal: Immunology Date: 1996-11 Impact factor: 7.397