| Literature DB >> 21490587 |
Kolitha Basnayake1, Stephanie J Stringer, Colin A Hutchison, Paul Cockwell.
Abstract
Kidney injury caused by immunoglobulin free light chains (FLCs) in the setting of plasma cell dyscrasias is common and associated with increased morbidity and mortality. All compartments of the kidney may be affected, from the glomerulus to the tubulointerstitium, in a wide variety of disease patterns. Here, we review our current knowledge of the biological effects of FLCs and the mechanisms that lead to kidney injury.Entities:
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Year: 2011 PMID： 21490587 DOI： 10.1038/ki.2011.94
Source DB: PubMed Journal: Kidney Int ISSN： 0085-2538 Impact factor: 10.612