BACKGROUND: MRI studies have shown a decreased cerebellum volume in individuals with ADHD. However, most of these studies were conducted with male children, many of whom were medicated with stimulants. As such, unmedicated, non-White girls are underrepresented in such MRI studies. OBJECTIVE: The aim of the present study was to compare the density of gray matter (GM) in the cerebellar hemisphere between unmedicated, non-White female children, adolescents, and adults diagnosed with ADHD combined type (ADHD-C) and healthy controls. METHOD: MRIs were performed on 11 Hispanic unmedicated ADHD-C children (6-10 years old), 8 Hispanic adolescents (14-17 years old), 10 Hispanic adults (25-35 years old), and the respective healthy controls. Image processing and statistical analyses were performed by Voxel Based Morphometry using the DARTEL algorithm to improve spatial normalization. RESULTS: Reduced GM density located in the right cerebellar hemisphere was found in female children, adolescents, and adults with ADHD-C. CONCLUSIONS: These findings suggest that there is an anatomical abnormality in the right cerebellar hemisphere in unmedicated Hispanic girls with ADHD-C that is present from childhood to adulthood.
BACKGROUND: MRI studies have shown a decreased cerebellum volume in individuals with ADHD. However, most of these studies were conducted with male children, many of whom were medicated with stimulants. As such, unmedicated, non-White girls are underrepresented in such MRI studies. OBJECTIVE: The aim of the present study was to compare the density of gray matter (GM) in the cerebellar hemisphere between unmedicated, non-White female children, adolescents, and adults diagnosed with ADHD combined type (ADHD-C) and healthy controls. METHOD: MRIs were performed on 11 Hispanic unmedicated ADHD-Cchildren (6-10 years old), 8 Hispanic adolescents (14-17 years old), 10 Hispanic adults (25-35 years old), and the respective healthy controls. Image processing and statistical analyses were performed by Voxel Based Morphometry using the DARTEL algorithm to improve spatial normalization. RESULTS: Reduced GM density located in the right cerebellar hemisphere was found in female children, adolescents, and adults with ADHD-C. CONCLUSIONS: These findings suggest that there is an anatomical abnormality in the right cerebellar hemisphere in unmedicated Hispanic girls with ADHD-C that is present from childhood to adulthood.
Authors: Erik Newman; Terry L Jernigan; Krista M Lisdahl; Leanne Tamm; Susan F Tapert; Steven G Potkin; Daniel Mathalon; Brooke Molina; James Bjork; F Xavier Castellanos; James Swanson; Joshua M Kuperman; Hauke Bartsch; Chi-Hua Chen; Anders M Dale; Jeffery N Epstein Journal: Brain Imaging Behav Date: 2016-09 Impact factor: 3.978
Authors: Matthew D Albaugh; Catherine Orr; Bader Chaarani; Robert R Althoff; Nicholas Allgaier; Nicholas D'Alberto; Kelsey Hudson; Scott Mackey; Philip A Spechler; Tobias Banaschewski; Rüdiger Brühl; Arun L W Bokde; Uli Bromberg; Christian Büchel; Anna Cattrell; Patricia J Conrod; Sylvane Desrivières; Herta Flor; Vincent Frouin; Jürgen Gallinat; Robert Goodman; Penny Gowland; Yvonne Grimmer; Andreas Heinz; Viola Kappel; Jean-Luc Martinot; Marie-Laure Paillère Martinot; Frauke Nees; Dimitri Papadopoulos Orfanos; Jani Penttila; Luise Poustka; Tomáš Paus; Michael N Smolka; Maren Struve; Henrik Walter; Robert Whelan; Gunter Schumann; Hugh Garavan; Alexandra S Potter Journal: Biol Psychiatry Date: 2017-01-13 Impact factor: 13.382
Authors: Benjamin Dirlikov; Keri Shiels Rosch; Deana Crocetti; Martha B Denckla; E Mark Mahone; Stewart H Mostofsky Journal: Neuroimage Clin Date: 2014-12-10 Impact factor: 4.881