BACKGROUND: Simple, low-cost methods are needed to evaluate the effect of zinc-fortification programs. Plasma zinc concentration is a useful biomarker of zinc intake from supplementation, but responses to zinc fortification are inconsistent. OBJECTIVE: The objective was to compare the change in plasma zinc concentrations in young children who received zinc from either a liquid supplement or a zinc-fortified complementary food. DESIGN: A double-blind intervention trial was conducted in 137 young Senegalese children aged 9-17 mo who were randomly assigned to receive one of the following treatments for 15 d: 1) 30 g dry weight of an iron-fortified cereal porridge and a liquid multivitamin supplement without zinc (control group), 2) the same porridge and multivitamin supplement with 6 mg Zn added to the supplement dose (ZnSuppl group), or 3) the same porridge with added zinc to provide 6 mg Zn per 25 g dry weight of porridge and multivitamin without zinc (ZnFort group). RESULTS:Mean (±SD) plasma zinc concentration (μg/dL) increased by 4.7 ± 1.6 (P = 0.004) in the ZnSuppl group, which was significantly greater (P = 0.009) than the mean change in the control group (-1.0 ± 1.6; P = 0.51) and in the ZnFort group (-1.8 ± 1.7; P = 0.29). The latter 2 groups did not differ from each other (P = 0.99). CONCLUSIONS:Plasma zinc concentration increased in children who received daily zinc supplementation for 15 d but not in those who received a zinc-fortified complementary food containing a similar amount of zinc. Additional longer-term studies are needed to assess the effect of zinc-fortification programs on zinc-related functional outcomes and the usefulness of plasma zinc as a biomarker of program effect. This trial was registered at www.clinicaltrials.gov as study NCT0094398.
RCT Entities:
BACKGROUND: Simple, low-cost methods are needed to evaluate the effect of zinc-fortification programs. Plasma zinc concentration is a useful biomarker of zinc intake from supplementation, but responses to zinc fortification are inconsistent. OBJECTIVE: The objective was to compare the change in plasma zinc concentrations in young children who received zinc from either a liquid supplement or a zinc-fortified complementary food. DESIGN: A double-blind intervention trial was conducted in 137 young Senegalese children aged 9-17 mo who were randomly assigned to receive one of the following treatments for 15 d: 1) 30 g dry weight of an iron-fortified cereal porridge and a liquid multivitamin supplement without zinc (control group), 2) the same porridge and multivitamin supplement with 6 mg Zn added to the supplement dose (ZnSuppl group), or 3) the same porridge with added zinc to provide 6 mg Zn per 25 g dry weight of porridge and multivitamin without zinc (ZnFort group). RESULTS: Mean (±SD) plasma zinc concentration (μg/dL) increased by 4.7 ± 1.6 (P = 0.004) in the ZnSuppl group, which was significantly greater (P = 0.009) than the mean change in the control group (-1.0 ± 1.6; P = 0.51) and in the ZnFort group (-1.8 ± 1.7; P = 0.29). The latter 2 groups did not differ from each other (P = 0.99). CONCLUSIONS: Plasma zinc concentration increased in children who received daily zinc supplementation for 15 d but not in those who received a zinc-fortified complementary food containing a similar amount of zinc. Additional longer-term studies are needed to assess the effect of zinc-fortification programs on zinc-related functional outcomes and the usefulness of plasma zinc as a biomarker of program effect. This trial was registered at www.clinicaltrials.gov as study NCT0094398.
Authors: Souheila Abbeddou; Sonja Y Hess; Elizabeth Yakes Jimenez; Jérôme W Somé; Stephen A Vosti; Rosemonde M Guissou; Jean-Bosco Ouédraogo; Kenneth H Brown Journal: Matern Child Nutr Date: 2015-12 Impact factor: 3.092
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Authors: Frank T Wieringa; Marjoleine A Dijkhuizen; Marion Fiorentino; Arnauld Laillou; Jacques Berger Journal: Nutrients Date: 2015-05-06 Impact factor: 5.717
Authors: K Ryan Wessells; Kenneth H Brown; Sengchanh Kounnavong; Maxwell A Barffour; Guy-Marino Hinnouho; Somphou Sayasone; Charles B Stephensen; Kethmany Ratsavong; Charles P Larson; Charles D Arnold; Kimberly B Harding; Gregory A Reinhart; Ganjana Lertmemongkolchai; Supan Fucharoen; Robin M Bernstein; Sonja Y Hess Journal: BMC Nutr Date: 2018-11-29
Authors: Ann Tarini; Mari S Manger; Kenneth H Brown; Mduduzi N N Mbuya; Laura A Rowe; Frederick Grant; Robert E Black; Christine M McDonald Journal: Nutrients Date: 2021-06-15 Impact factor: 5.717
Authors: Jérôme W Somé; Souheila Abbeddou; Elizabeth Yakes Jimenez; Sonja Y Hess; Zinéwendé P Ouédraogo; Rosemonde M Guissou; Stephen A Vosti; Jean-Bosco Ouédraogo; Kenneth H Brown Journal: BMJ Open Date: 2015-09-11 Impact factor: 2.692